POLYIODINATED TRIGLYCERIDES AS LIVER CONTRAST AGENTS

本项目的目的是评估和比较两种新的聚碘 作为肝成像的放射造影剂的甘油三酯衍生物 CT（Computed Tomography） 这些新的亲脂性造影剂包括 通常使用的放射造影剂碘番酸或其 将conjener去乙基番酸酯化到 甘油分子 我们实验室的初步工作已经证明 这些碘辛酸甘油三酯具有相当大的潜力， 肝特异性CT造影剂。 这些试剂将配制为 脂肪乳剂类似于胃肠外高营养 Intraperoid和Liposyn。 包含在具体目标的范围内 以下是目标：1）合成足够量的 新的甘油三酯碘番酸酯; 2）优化技术， 将这些试剂制成乳剂，类似于用于人类的乳剂， 肝透明化的研究 这些代理人在正常和荷瘤兔的性能。 的 这些研究的结果将确定进一步的合理性， 在II期随访研究中对这些药物进行研究。

The aim of this project is to evaluate and compare two new polyiodinated triglyceride derivatives as radiologic contrast agents for hepatic imaging by computed tomography (CT). These new lipophilic contrast agents consist of either the commonly used radiologic contrast agent iopanoic acid or its conjener desethyliopanoic acid esterified to the 1 and 3-position of the glycerol molecule. Preliminary work in our laboratories has demonstrated that these triglyceride iopanoates have considerable potential as hepatic-specific CT contrast agents. These agents will be formulated as lipid emulsions similar to the paventeral hyperalimentation emulsious Intralipid and Liposyn. Encompassed within the scope of the specific aims are the following objectives: 1) to synthesize adequate quantities of the new triglyceride iopanoates; 2) to optimize techniques for incorporating these agents into emulsions analogous to those used in humans for paventeval hypervalimentation; and 3) to study the hepatic opacification properties of these agents in normal and tumor-bearing rabbits. The results from these studies will determine the justification of further investigation of these agents in a Phase II follow-up study.