Small Animal Imaging

小动物成像

• 批准号: 8250415
• 负责人: JAMEY P WEICHERT
• 金额: $ 14.42万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8250415
• 关键词: Anatomy; Anesthesia procedures; Animal Model; Animals; Beds; Biological; Cells; Comprehensive Cancer Center; Consultations; Contrast Media; Coupled; Data Set; Detection; Evaluation; Gases; Hybrids; Image; Isoflurane; Manufacturer Name; Methodology; Mission; Modality; Physiologic Monitoring; Proteins; Radiochemistry; Radiolabeled; Rattus; Research; Research Personnel; Resolution; Rodent; Scanning; Schedule; System; Technology; detector; in vivo; innovation; member; radiotracer; reconstruction; small molecule; tumor

The UWCCC Small Animal Imaging Facility provides innovative, state-of-the-art, affordable, noninvasive, high-resolution in-vivo and ex-vivo imaging support to UWCCC members who utilize small animal models in their research. The facility director and manager provide consultation with investigators about methodologies most suited to answer their biological questions. Investigators are able to select various levels of support ranging from image acquisition alone, to acquisition and reconstruction, to image interpretation and finally to media presentation. Because of their radiochemistry expertise, they also radiolabel small molecules or proteins for investigators prior to imaging. Anatomic MicroCT Scanning. A MicroCAT-2 from Siemens/CTI is equipped with a large field-of-view detector, thus allowing high resolution scanning (18 micron)'of rats up to 300 grams. The system is equipped with a rodent isoflurane gas anesthesia system and physiologic monitoring system which allows image gating, Functional MicroPET Scanning. Functional microPET imaging is also available. Because both scanners are from the same manufacturer, the scanning beds are completely interchangeable which allows scanning with both modalities without moving the animal, thus allowing fairly accurate fusion of the two data sets. We are scheduled to acquire the first commercial microCT/microPET hybrid scanner from Siemens/CTI in June of 2006. This world's first hybrid scanner coupled with our own proprietary cell-selective imaging and contrast agents affords our investigators unique tumor detection and evaluation technologies which can only be provided here.

UWCCC小动物成像设施提供创新的，最先进的，负担得起的，非侵入性的， 高分辨率的体内和体外成像支持UWCCC成员谁利用小动物模型， 他们的研究。设施主任和经理与调查人员进行协商， 最适合回答他们的生物学问题的方法。调查人员可以选择各种 支持级别从单独的图像采集到采集和重建，再到图像 最后是媒体介绍。由于他们的放射化学专业知识，他们也 在成像前为研究者进行放射性标记的小分子或蛋白质。 解剖显微CT扫描。Siemens/CTI的MicroCAT-2配备了大视场 探测器，从而允许高分辨率扫描（18微米）的大鼠高达300克。系统配备 使用啮齿动物异氟烷气体麻醉系统和生理监测系统， 选通， 功能性MicroPET扫描。功能性microPET成像也可用。因为两台扫描仪 来自同一个制造商，扫描床是完全可互换的， 这两种模式都不需要移动动物，因此允许两个数据集的相当准确的融合。 我们计划于2010年从Siemens/CTI收购第一台商用microCT/microPET混合扫描仪。 2006年6月这是世界上第一台混合扫描仪，结合我们自己专有的细胞选择性成像技术， 造影剂为我们的研究者提供了独特的肿瘤检测和评估技术， 在这里提供。