Small Animal Imaging

小动物成像

• 批准号: 7491891
• 负责人: JAMEY P WEICHERT
• 金额: $ 15.17万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-23 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7491891
• 关键词: Anatomy; Anesthesia procedures; Animal Model; Animals; Arts; Beds; Biological; Cells; Consultations; Contrast Media; Coupled; Data Set; Detection; Evaluation; Gases; Hybrids; Image; Isoflurane; Manufacturer Name; Methodology; Mission; Modality; Physiologic Monitoring; Proteins; Radiochemistry; Radiolabeled; Range; Rattus; Research; Research Personnel; Resolution; Rodent; Scanning; Schedule; System; Technology; detector; in vivo; innovation; member; radiotracer; reconstruction; small molecule; tumor

The UWCCC Small Animal Imaging Facility provides innovative, state-of-the-art, affordable, noninvasive, high-resolution in-vivo and ex-vivo imaging support to UWCCC members who utilize small animal models in their research. The facility director and manager provide consultation with investigators about methodologies most suited to answer their biological questions. Investigators are able to select various levels of support ranging from image acquisition alone, to acquisition and reconstruction, to image interpretation and finally to media presentation. Because of their radiochemistry expertise, they also radiolabel small molecules or proteins for investigators prior to imaging. Anatomic MicroCT Scanning. A MicroCAT-2 from Siemens/CTI is equipped with a large field-of-view detector, thus allowing high resolution scanning (18 micron)'of rats up to 300 grams. The system is equipped with a rodent isoflurane gas anesthesia system and physiologic monitoring system which allows image gating, Functional MicroPET Scanning. Functional microPET imaging is also available. Because both scanners are from the same manufacturer, the scanning beds are completely interchangeable which allows scanning with both modalities without moving the animal, thus allowing fairly accurate fusion of the two data sets. We are scheduled to acquire the first commercial microCT/microPET hybrid scanner from Siemens/CTI in June of 2006. This world's first hybrid scanner coupled with our own proprietary cell-selective imaging and contrast agents affords our investigators unique tumor detection and evaluation technologies which can only be provided here.

UWCCC小动物成像设备提供创新的，最先进的，价格合理的，无创的，