NOVEL HIGH SURFACE AREA INTERLOCKING COMPOSITE FILMS

新型高表面积联锁复合薄膜

• 批准号: 3500924
• 负责人: VICTOR R KOCH
• 金额: $ 5万
• 依托单位: COVALENT ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-08-01 至 1987-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3500924
• 关键词: adhesions; biomaterial development /preparation; biomaterial interface interaction; biomaterials; clinical biomedical equipment; electrical conductance; electrochemistry; molecular film; polymerization; polymers; scanning electron microscopy; thiophenes

A need exists to develop robust, adhesive insulating coatings for biomedical hardware implanted in vivo. Although many organic polymers have been found to be biocompatible, long-term adhesion to metal substrates has yet to be achieved. We propose to prepare novel composite films which interlock with each other as well as with an etched metal substrate. High surface area primer coatings will be electrochemically generated on Pt substrates. Scanning electron microscopy and electrochemical techniques will assess the surface morphology and coherence. These high surface area primer coatings will then be interlocked with Paralene and tested for adhesivity at the University of Missouri (Columbia). The ultimate goal of this work is to provide the biomedical community in general and NIH in particular with superior insulating composite coatings for implantable hardware.

需要开发坚固的粘结性绝缘涂料，用于 植入体内的生物医学硬件。尽管许多有机聚合物具有 已被发现是生物相容的，与金属基材的长期粘附性 还没有实现。 我们建议制备相互连锁的新型复合膜。 以及蚀刻的金属衬底。高表面积底漆 涂层将在铂衬底上电化学生成。正在扫描 电子显微镜和电化学技术将评估表面 形态和连贯性。这些高表面积底漆将 然后与Paralene互锁并在 密苏里大学(哥伦比亚)。这项工作的最终目标是 为生物医学界特别是美国国立卫生研究院提供 用于植入式五金的优质绝缘复合涂层。