ELECTROPOLYMERIZED INTERLOCKING COMPOSITE COATINGS

电聚合互锁复合涂层

• 批准号: 3508550
• 负责人: VICTOR R KOCH
• 金额: $ 24.81万
• 依托单位: COVALENT ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-08-01 至 1991-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3508550
• 关键词: adhesions; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; infrared spectrometry; polymerization; polymers

A persistent problem inhibiting both the development of implantable neural prosthesis for the neurologically handicapped and robust circulatory system hardware involves the passivation and non-hermetic protection of metallic implants. These devices include stimulating electrodes, signal processing integrated circuits, cardiac pacemakers, and drug delivery systems. To address this problem, thin, conformal, biocompatible coatings are required which passivate a variety of substrate surface and have lifetimes measured in years. Although polymeric materials such as Teflon, Silastic, and the Parylenes have excellent chemical and biochemical properties, poor adhesion of the organic coating to the device surface has been the Achilles' heel in virtually every application. During Phase I we demonstrated the feasibility of mechanically interlocking a Parylene topcoat to an electropolymerized primer coating. Our primer is an electrochemically conducting organic polymer. This feature allowed us to electrochemically generate a morphologically rough surface which facilitated the formation of an interlocked composite coating. Post Phase I work with non-conducting electropolymerized organic polymers indicated that these coatings could be intimately interlocked with the conducting primer coat thereby yielding a highly insulating, adherent composite film. In Phase II we will investigate the interfacial nature of the metal/primer/topcoat composite by a variety of electroanalytical and spectroscopic techniques. Means of improving the metal/primer interface and primer/topcoat interface will be explored. Finally, we will coat implantable cardiac hardware supplied to us by a vendor for subsequent evaluation by them.

一个长期存在的问题，既制约着植入性疾病的发展 神经性残障和健全者的神经假体 循环系统硬件涉及钝化和非密闭 金属植入物的保护。这些装置包括刺激 电极、信号处理集成电路、心脏起搏器、 和药物输送系统。为了解决这个问题，薄的，保形的， 需要生物兼容涂层来钝化各种 基片表面，使用寿命以年为单位。虽然 聚四氟乙烯、硅橡胶和对二甲苯等聚合材料具有 优良的化学和生化性能，粘附性差 设备表面的有机涂层一直是设备的致命弱点 几乎所有的应用程序。 在第一阶段中，我们从机械上论证了 将一种聚对二甲苯面漆与电聚合底漆互锁。 我们的底漆是一种电化学导电的有机聚合物。这 这一特征使我们能够电化学地产生一种形态上的粗糙 有利于形成互锁复合材料的表面 涂层。非导电电聚合体的第一阶段后工作 有机聚合物表明，这些涂层可以紧密地 与导电底漆互锁，从而产生高度的 绝缘、粘合的复合膜。 在第二阶段中，我们将调查界面性质 金属/底漆/面漆由各种电分析和表面涂层组成 光谱技术。改善金属/底漆界面的方法 并探索底漆/面漆的界面。最后，我们会穿上外套 由供应商提供给我们的植入式心脏硬件，用于后续 由他们进行评估。