ELECTROPOLYMERIZED INTERLOCKING COMPOSITE COATINGS

电聚合互锁复合涂层

• 批准号: 3508549
• 负责人: VICTOR R KOCH
• 金额: $ 25.19万
• 依托单位: COVALENT ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-08-01 至 1991-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3508549
• 关键词: adhesions; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; infrared spectrometry; polymerization; polymers

A persistent problem inhibiting both the development of implantable neural prosthesis for the neurologically handicapped and robust circulatory system hardware involves the passivation and non-hermetic protection of metallic implants. These devices include stimulating electrodes, signal processing integrated circuits, cardiac pacemakers, and drug delivery systems. To address this problem, thin, conformal, biocompatible coatings are required which passivate a variety of substrate surface and have lifetimes measured in years. Although polymeric materials such as Teflon, Silastic, and the Parylenes have excellent chemical and biochemical properties, poor adhesion of the organic coating to the device surface has been the Achilles' heel in virtually every application. During Phase I we demonstrated the feasibility of mechanically interlocking a Parylene topcoat to an electropolymerized primer coating. Our primer is an electrochemically conducting organic polymer. This feature allowed us to electrochemically generate a morphologically rough surface which facilitated the formation of an interlocked composite coating. Post Phase I work with non-conducting electropolymerized organic polymers indicated that these coatings could be intimately interlocked with the conducting primer coat thereby yielding a highly insulating, adherent composite film. In Phase II we will investigate the interfacial nature of the metal/primer/topcoat composite by a variety of electroanalytical and spectroscopic techniques. Means of improving the metal/primer interface and primer/topcoat interface will be explored. Finally, we will coat implantable cardiac hardware supplied to us by a vendor for subsequent evaluation by them.

一个长期存在的问题，既抑制了植入式 用于神经残疾和健壮的神经假体 循环系统硬件涉及钝化和非密封 金属植入物的保护。 这些设备包括刺激 电极，信号处理集成电路，心脏起搏器， 和药物输送系统。 为了解决这个问题，薄，适形， 需要生物相容性涂层， 衬底表面，并具有以年为单位测量的寿命。 虽然 聚合物材料如特氟隆、硅橡胶和聚对二甲苯具有 优良的化学和生物化学性能， 有机涂层的设备表面一直是阿喀琉斯之踵， 几乎所有的应用程序。 在第一阶段，我们证明了机械的可行性， 将聚对二甲苯面漆与电聚合底漆涂层互锁。 我们的底漆是一种电化学导电有机聚合物。 这 特征使我们能够电化学生成一个形态粗糙的 有助于形成互锁复合材料的表面 涂层 第一阶段后，使用非导电电聚合 有机聚合物表明，这些涂层可以密切 与导电底漆层互锁，从而产生高度 绝缘、粘附复合膜。 在第二阶段，我们将研究的界面性质的 金属/底漆/面漆复合材料通过各种电分析和 光谱技术 改善金属/底漆界面的方法 以及底漆/面漆界面。 最后，我们将 由供应商提供给我们的植入式心脏硬件 他们的评价。