MUSSEL-ADHESIVE PROTEIN: A NEW TISSUE-ADHESIVE

贻贝粘附蛋白：一种新的组织粘附剂

• 批准号: 3496859
• 负责人: PAUL T PICCIANO
• 金额: $ 4.78万
• 依托单位: BIOPOLYMERS, INC.
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-04-01 至 1987-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3496859
• 关键词: adhesions; biomaterial evaluation; cornea; eye surgery; keratoplasty; retina; surgery material /equipment; wound healing

Considerable effort has been focused on the use of cyanoacrylates for clinical ocular repair as adjuncts to or in lieu of surgical procedures. Through repeated studies, however, these adhesives have proved to be damaging to the eye tissue by causing inflammation, neovascularization and tissue necrosia. As an alternative to cyanoacrylates, this project proposes the use of mussel-adhesive protein (MAP) as a tissue adhesive in ocular repair. Experiments will be conducted with MAP on retinal and corneal tissue in vitro and in situ, and evaluated for strength and duration of tissue bonding. MAP is a strong adhesive cement and, unlike cyanoacrylates, appears to be biocompatible, and will likely add an attractive alternative for the treatment of ocular injuries.

相当大的努力集中在使用氰基丙烯酸酯， 作为外科手术的补充或替代的临床眼部修复。 然而，通过反复研究，这些粘合剂已被证明是 通过引起炎症、新血管形成和 组织坏死 作为氰基丙烯酸酯的替代品，该项目 提出了贻贝粘附蛋白（MAP）作为组织粘合剂的用途， 眼部修复 将用MAP对视网膜进行实验， 体外和原位角膜组织，并评估强度和 组织粘合的持续时间。 MAP是一种强力粘合剂， 氰基丙烯酸酯，似乎是生物相容的，并可能会增加一个 治疗眼部损伤的有吸引力的替代方案。