3-D REAL TIME X-RAY RECONSTRUCTION OF CORONARY STENOSIS

冠状动脉狭窄的 3D 实时 X 射线重建

• 批准号: 3500728
• 负责人: WOLFRAM R JARISCH
• 金额: $ 5万
• 依托单位: CYBER TECHNOLOGY, INC.
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-04-01 至 1986-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3500728
• 关键词: artery stenosis; cineangiocardiography; cineradiography; computer graphics /printing; coronary artery; image processing

Precision in the estimation of the severity of coronary artery disease is critical for evaluating the long-term effects of therapeutic interventions such as diet, lipid-lowering drugs, coronary bypass surgery, and balloon angioplasty (PTCA), as well as assessing prognosis and choosing the appropriate form of therapy for each individual patient. Visual interpretation of the coronary arteriogram is today the gold standard for defining the pathoanatomy in coronary heart disease. However, there are inherent limitations in this method of interpretation. Typically, the observer will derive an estimate of the percent of vessel diameter narrowing by looking at and averaging 2 views taken at right angles to each other. A significant error of estimating lumen-size may result when an atherosclerotic plaque is not perfectly round or concentrically located within the lumen; in fact, the majority of lesions are eccentric and many have irregular shapes. This proposal is to develop an improved, objective method for 3-dimensional reconstruction of coronary angiographic data. This will be achieved by applying refinements of a novel algorithm (developed by the PI) to already developed computerized densitometric techniques (developed by one of our consultants). The algorithm is rapid, and may readily be applied to a large number of image frames. The goal of the effort is to develop a real-time algorithm for angiographic data, which will allow for reliable decisions for choosing therapy, and immediate decisions while doing balloon angioplasty. The algorithm is also expected to have widespread applications in industry.

冠状动脉疾病严重程度估计的精确度 对于评估治疗干预的长期效果至关重要 如饮食、降脂药物、冠状动脉搭桥手术和气球 血管成形术（PTCA），以及评估预后和选择 为每位患者提供合适的治疗方案。 冠状动脉造影的视觉解释是今天的黄金 定义冠心病病理解剖学的标准。 然而，在这方面， 这种解释方法有其固有的局限性。 通常情况下，观察员将得出血管百分比的估计值， 通过查看并平均右侧的2个视图缩小直径 彼此的角度。 估计内腔尺寸的显著误差可能 当动脉粥样硬化斑块不是完美的圆形时， 同心地位于管腔内;事实上，大多数病变 是偏心的，许多具有不规则的形状。 该建议是开发一种改进的，客观的三维方法， 冠状动脉造影数据的重建。 为实现这些目标将 应用一种新算法的改进（由PI开发）， 开发了计算机化的密度测定技术（由我们的一个 顾问）。 该算法是快速的，并且可以容易地应用于 大量的图像帧。 这项工作的目标是开发一种血管造影的实时算法， 数据，这将允许选择治疗的可靠决策，以及 在做球囊血管成形术时立即做出决定。 该算法还 有望在工业上得到广泛应用。