3D DYNAMIC VISUALIZATION OF CARDIAC MUSCLE PERFUSION

心肌灌注的 3D 动态可视化

• 批准号: 3502428
• 负责人: WOLFRAM R JARISCH
• 金额: $ 5万
• 依托单位: CYBER TECHNOLOGY, INC.
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-06-01 至 1993-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3502428
• 关键词: angiocardiography; biomedical automation; computer program /software; contrast media; diagnosis design /evaluation; dogs; heart circulation; muscle contraction; radiography

Visual interpretation of the x-ray coronary arteriogram is today the gold standard for defining the pathoanatomy in coronary heart disease. There are inherent limitations, however, in this method of interpretation. In particular, arterial flow rates are needed to estimate the degree of regional insufficiency of blood supply. Despite the arteriogram's central role it permits only indirect and crude estimates of flow rates. Efforts to use the 'time-of-flight' method to estimate x-ray dye flow rates have not been successful clinically. The procedure is complex and has been limited to the less informative projective images. This proposal is to implement a direct automated measurement technique to evaluate regional muscle perfusion in 3-D. The new technique utilizes the x-ray projection angiographic data. However, rather than reconstructing in 3-D the initial phase of the injection of the contrast dye, the late portion of the injection is reconstructed. This late phase exhibits large pulsatile levels of contrast dye in the sponge-like muscle. From the pulsatile rates of clearance and re-supply of the dye, and the magnitude of these pulses, relative flow rates and muscular contractility are computed in 3-D. These important cardiac parameters have been elusive so far. Their measurement constitutes an important innovation for the goal of this effort to improve the choice of therapy in coronary heart disease and immediate decision while doing PTCA.

X光冠状动脉造影的视觉解释是今天的黄金 定义冠心病病理解剖学的标准。 那里 然而，在这种解释方法中存在固有的局限性。 在 特别地，需要动脉流速来估计动脉硬化的程度。 局部供血不足。 尽管动脉造影显示 它只允许对流量进行间接和粗略的估计。 努力使用'飞行时间'方法来估计X射线染料流 但在临床上并不成功。 程序复杂， 仅限于信息量较少的投影图像。 本提案旨在实施直接自动测量技术， 评估局部肌肉的三维灌注。 新技术利用 X射线投影血管造影数据。 然而，与其 在3D中重建造影剂注射的初始阶段 染料，重建注射的后期部分。 这个晚期阶段 在海绵状血管中显示出大的脉冲水平的造影剂 肌肉. 从清除和再供给染料的脉动率来看， 以及这些脉冲的幅度、相对流速和肌肉的 收缩力以三维形式计算。 这些重要的心脏参数 目前还很难找到 它们的测量构成了重要的 创新的目标，这一努力，以改善治疗的选择， 在冠心病和立即决定，而做PTCA。