CHEMISTRY AND BIOCHEMISTRY OF AQUATIC TOXINS

水生毒素的化学和生物化学

基本信息

  • 批准号:
    3484648
  • 负责人:
  • 金额:
    $ 17.77万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1980
  • 资助国家:
    美国
  • 起止时间:
    1980-09-01 至 1995-06-30
  • 项目状态:
    已结题

项目摘要

The proposed research is to elucidate the chemistry and biosynthesis of algal and other aquatic toxins which have serious impact on public health. The chemical work is intended to provide basic information to design preventive and curative measures, and also to discover new site-specific toxins as tools to investigate important biological mechanisms involving neural receptors such as sodium channels and glutamate receptors. The biosynthesis work is intended to elucidate the sites of formation and unique metabolic pathways in aquatic organisms. The resulting information will help to consider such important issues as the virulency acquisition of red tide organisms and marine animals, and the mass production of important marine products. Specifically, the structures, distribution, and biosynthesis of 1) excitatory amino acids such as domoic acid and kainic acid; 2) paralytic shellfish poisons (PSP) such as saxitoxin and gonyautoxins; 3) polyether toxins such as brevetoxins and okadaic acid derivatives; 4) blue-green algal toxins such as cyanoginosins and aphanorphin; 5) tetrodotoxin and its derivatives will be investigated. The work will involve the culturing of organisms, analysis and purification of toxins using chromatographic methods, structure elucidation by modern spectroscopic methods such as 2D-NMR and X-ray crystallography, and isotope labeling studies using both stable and radioactive isotopes. Isolated toxins will be provided to neurophysiologists for pharmacological studies.
提出的研究是阐明的化学和生物合成

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

YUZURU SHIMIZU其他文献

YUZURU SHIMIZU的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('YUZURU SHIMIZU', 18)}}的其他基金

BRIN: URI: TMSR/TOXINS & NATURAL DRUGS SUBCORE
BRIN: URI: TMSR/毒素
  • 批准号:
    6973516
  • 财政年份:
    2004
  • 资助金额:
    $ 17.77万
  • 项目类别:
ANTITUMOUR AGENTS FROM MARINE MICROALGAE
来自海洋微藻的抗肿瘤剂
  • 批准号:
    6203315
  • 财政年份:
    1999
  • 资助金额:
    $ 17.77万
  • 项目类别:
ANTITUMOUR AGENTS FROM MARINE MICROALGAE
来自海洋微藻的抗肿瘤剂
  • 批准号:
    6237577
  • 财政年份:
    1997
  • 资助金额:
    $ 17.77万
  • 项目类别:
ANTITUMOR, ANTIVIRAL AGENTS IN MICROALGAE
微藻中的抗肿瘤、抗病毒剂
  • 批准号:
    3194365
  • 财政年份:
    1989
  • 资助金额:
    $ 17.77万
  • 项目类别:
ANTITUMOR, ANTIVIRAL AGENTS IN MICROALGAE
微藻中的抗肿瘤、抗病毒剂
  • 批准号:
    2093566
  • 财政年份:
    1989
  • 资助金额:
    $ 17.77万
  • 项目类别:
ANTITUMOR, ANTIVIRAL AGENTS IN MICROALGAE
微藻中的抗肿瘤、抗病毒剂
  • 批准号:
    3194362
  • 财政年份:
    1989
  • 资助金额:
    $ 17.77万
  • 项目类别:
ANTITUMOR, ANTIVIRAL AGENTS IN MICROALGAE
微藻中的抗肿瘤、抗病毒剂
  • 批准号:
    3194364
  • 财政年份:
    1989
  • 资助金额:
    $ 17.77万
  • 项目类别:
ANTITUMOR, ANTIVIRAL AGENTS IN MICROALGAE
微藻中的抗肿瘤、抗病毒剂
  • 批准号:
    3194363
  • 财政年份:
    1989
  • 资助金额:
    $ 17.77万
  • 项目类别:
CHEMISTRY AND BIOCHEMISTRY OF AQUATIC TOXINS
水生毒素的化学和生物化学
  • 批准号:
    2175266
  • 财政年份:
    1980
  • 资助金额:
    $ 17.77万
  • 项目类别:
CHEMISTRY AND BIOCHEMISTRY OF AQUATIC TOXINS
水生毒素的化学和生物化学
  • 批准号:
    2734429
  • 财政年份:
    1980
  • 资助金额:
    $ 17.77万
  • 项目类别:

相似海外基金

ERI: Characterizing and improving algae-derived biofuel droplet burning
ERI:表征和改善藻类生物燃料液滴燃烧
  • 批准号:
    2301490
  • 财政年份:
    2024
  • 资助金额:
    $ 17.77万
  • 项目类别:
    Standard Grant
North Carolina Center for Coastal Algae, People, and Environment NC-CAPE
北卡罗来纳州沿海藻类、人类和环境中心 NC-CAPE
  • 批准号:
    2414792
  • 财政年份:
    2024
  • 资助金额:
    $ 17.77万
  • 项目类别:
    Continuing Grant
Investigating biosynthesis of the newly discovered natural product euglenatide and distribution across the breadth of Euglenoid algae
研究新发现的天然产物眼虫肽的生物合成及其在眼虫类藻类中的分布
  • 批准号:
    EP/Y003314/1
  • 财政年份:
    2024
  • 资助金额:
    $ 17.77万
  • 项目类别:
    Research Grant
Pathogens of Algae for Biocontrol and Biosecurity
用于生物防治和生物安全的藻类病原体
  • 批准号:
    EP/Y036808/1
  • 财政年份:
    2024
  • 资助金额:
    $ 17.77万
  • 项目类别:
    Research Grant
Molecular fossils, mass extinctions and the rise of complex algae
分子化石、大规模灭绝和复杂藻类的兴起
  • 批准号:
    DP240100281
  • 财政年份:
    2024
  • 资助金额:
    $ 17.77万
  • 项目类别:
    Discovery Projects
CORAL:Compostable Foams from Renewable Algae Sources: development and identification of strategies for their implementation
珊瑚:可再生藻类来源的可堆肥泡沫:制定和确定其实施策略
  • 批准号:
    EP/Y027701/1
  • 财政年份:
    2024
  • 资助金额:
    $ 17.77万
  • 项目类别:
    Fellowship
Species identification, ecological elucidation, and resource value assessment of filamentous fungi parasitic on terrestrial plants and algae in polar regions
极地陆生植物和藻类寄生丝状真菌的物种鉴定、生态解析及资源价值评估
  • 批准号:
    23K11504
  • 财政年份:
    2023
  • 资助金额:
    $ 17.77万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Carbon sequestration and sustainable product manufacture by algae using a novel photo-bioreactor
使用新型光生物反应器通过藻类进行碳封存和可持续产品制造
  • 批准号:
    2831630
  • 财政年份:
    2023
  • 资助金额:
    $ 17.77万
  • 项目类别:
    Studentship
Elucidation of the molecular mechanisms driving the co-evolution between red tide-causing algae and viruses
阐明驱动赤潮藻类与病毒共同进化的分子机制
  • 批准号:
    23K14265
  • 财政年份:
    2023
  • 资助金额:
    $ 17.77万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Unravelling the genetic basis of the gamete recognition system in brown algae
揭示褐藻配子识别系统的遗传基础
  • 批准号:
    23K19386
  • 财政年份:
    2023
  • 资助金额:
    $ 17.77万
  • 项目类别:
    Grant-in-Aid for Research Activity Start-up
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了