CHEMISTRY AND BIOCHEMISTRY OF AQUATIC TOXINS
水生毒素的化学和生物化学
基本信息
- 批准号:3484648
- 负责人:
- 金额:$ 17.77万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1980
- 资助国家:美国
- 起止时间:1980-09-01 至 1995-06-30
- 项目状态:已结题
- 来源:
- 关键词:Bivalvia algae antineoplastics aquatic biology chemical structure chemical structure function drug metabolism drug screening /evaluation environmental toxicology fresh water environment immunochemistry laboratory mouse membrane channels microorganism antigen neuropharmacology neurophysiology neurotoxins nuclear magnetic resonance spectroscopy radiotracer saltwater environment saxitoxin seafood poisoning tetrodotoxin
项目摘要
The proposed research is to elucidate the chemistry and biosynthesis of
algal and other aquatic toxins which have serious impact on public health.
The chemical work is intended to provide basic information to design
preventive and curative measures, and also to discover new site-specific
toxins as tools to investigate important biological mechanisms involving
neural receptors such as sodium channels and glutamate receptors. The
biosynthesis work is intended to elucidate the sites of formation and
unique metabolic pathways in aquatic organisms. The resulting information
will help to consider such important issues as the virulency acquisition of
red tide organisms and marine animals, and the mass production of important
marine products.
Specifically, the structures, distribution, and biosynthesis of 1)
excitatory amino acids such as domoic acid and kainic acid; 2) paralytic
shellfish poisons (PSP) such as saxitoxin and gonyautoxins; 3) polyether
toxins such as brevetoxins and okadaic acid derivatives; 4) blue-green
algal toxins such as cyanoginosins and aphanorphin; 5) tetrodotoxin and its
derivatives will be investigated.
The work will involve the culturing of organisms, analysis and purification
of toxins using chromatographic methods, structure elucidation by modern
spectroscopic methods such as 2D-NMR and X-ray crystallography, and isotope
labeling studies using both stable and radioactive isotopes. Isolated
toxins will be provided to neurophysiologists for pharmacological studies.
提出的研究是阐明的化学和生物合成
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('YUZURU SHIMIZU', 18)}}的其他基金
BRIN: URI: TMSR/TOXINS & NATURAL DRUGS SUBCORE
BRIN: URI: TMSR/毒素
- 批准号:
6973516 - 财政年份:2004
- 资助金额:
$ 17.77万 - 项目类别:
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