BIOCHEMICAL MODEL REACTIONS

将继续进行人造酶的研究。 其中包括化合物 将环糊精、吡哆醛或吡哆胺与结合基团结合， 如环糊精、大环化合物或类固醇;适当放置 碱性催化基团也将用于促进特定过程。 酶反应的特性--对底物、对 化学反应，对于底物的区域，以及对于 底物和产物将被模仿。 硫胺素相关酶的研究 模拟也将继续进行，因为将致力于合成和研究 疏水笼状分子。 这些系统的设计将得到以下方面的帮助： 计算机模拟方法 将继续进行催化剂的设计工作 利用一种新开发的分析技术， 的研究 疏水催化剂催化Diels-Alder反应和相关过程 将追求效果和笼型催化剂，强调选择性。 工作 也将致力于产生肽切割的良好模拟物， 合成酶

Work on artificial enzymes will be pursued. This includes compounds combining cyclodextrins, pyridoxal or pyridoxamine with binding groups, such as cyclodextrins, macrocycles, or steroids; appropriate placement of basic catalytic groups will also be used to promote specific processes. The characteristic specificities of enzyme reactions--for substrate, for chemical reaction, for region of the substrate, and for stereochemistry of substrate and produce--will be mimicked. Work on thiamine related enzyme mimics will also be pursued, as will work on the synthesis and study of the hydrophobic cage molecules. Design of these syst;ems will be assisted by computer modeling methods. Work will be pursued on the design of catalysts that cleave RNA, using a newly developed assay technique. Studies of the catalysis of Diels-Alder reactions and related processes by hydrophobic effects and cage catalysts will be pursued, emphasizing selectivity. Work will also be directed at producing good mimics of peptide-cleaving and synthesizing enzymes.