Virtual Formulation Laboratory for prediction and optimisation of manufacturability of advanced solids based formulations

虚拟配方实验室,用于预测和优化先进固体配方的可制造性

基本信息

  • 批准号:
    EP/N025261/1
  • 负责人:
  • 金额:
    $ 221.96万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2017
  • 资助国家:
    英国
  • 起止时间:
    2017 至 无数据
  • 项目状态:
    已结题

项目摘要

Solid dose forms are the backbone of many manufacturing industries. In pharmaceutical therapeutics, tablets, capsules, dry powder inhalers and powders for re-suspension cover the vast majority of the £5.6Bn sales by this industry in the UK. Food (sales £67Bn) is the single largest industry of the UK manufacturing sector which totalled £365Bn sales in 2014 (Office of National Statistics). In all these manufacturing processes and in final use, the physical behaviour of the powder is at least as important as the chemistry. Stability, weight and content uniformity, manufacturing difficulties and variable performance are determined by decisions made during the formulation process Manufacturing problems are ubiquitous; the Rand report (by E.W. Merrow, 1981) examined powder processes and found on average 2 year over-runs to get to full productivity, and development costs 210% of estimates, due to incompatibility between powder behaviour and process design. In the intervening years, plant engineering techniques have developed, but the rationalisation of formulation decisions has never received more than cursory, empirical study. This project proposes to develop a Virtual Formulation Laboratory (VFL), a software tool for prediction and optimisation of manufacturability and stability of advanced solids-based formulations. The team has established expertise in powder flow, mixing and compaction which will be brought together for the first time to link formulation variables with manufacturability predictions. The OVERALL AIMS of the project are (a) to develop the science base for understanding of surfaces, particulate structures and bulk behaviour to address physical, chemical and mechanical stability during processing and storage and (b) to incorporate these into a software tool (VFL) which accounts for a wide range of material types, particle structures and blend systems to enable the formulator to test the effects of formulation changes in virtual space and check for potential problems covering the majority of manufacturing difficulties experienced in production plants. The VISION for VFL is to be employed widely in the development process of every new formulated powder product in food, pharmaceuticals and fine chemicals within five years of the completion of this project. VFL will consider four processes: powder flow, mixing, compaction and storage; and will predict four manufacturability problems: poor flow/flooding, segregation/heterogeneity, powder caking and strength/breakage of compacts These account for the majority of practical problems in the processing of solid particulate materials The OVERALL OBJECTIVES of the project are: (a) to fill the gaps in formulation science to link molecule to manufacturability, which will be achieved through experimental characterisation and numerical modelling, and (b) establish methodologies to deal with new materials, so that the virtual lab could make predictions for formulations with new materials without extensive experimental characterisation or numerical modelling. This will be achieved through developing functional relationships based on the scientific outcomes of the above investigations, while identifying the limits and uncertainties of these relationships.
固体剂型是许多制造业的支柱。在药物疗法方面,片剂、胶囊、干粉吸入器和再悬浮粉占该行业在英国56亿GB销售额的绝大多数。食品(销售额670亿GB)是英国制造业中最大的行业,2014年销售额总计3650亿GB(英国国家统计局)。在所有这些制造过程和最终使用中,粉末的物理行为至少与化学行为一样重要。稳定性、重量和含量均匀度、制造困难和可变性能由配方过程中做出的决定决定;制造问题无处不在;兰德报告(E.W.Merrow,1981)检查了粉末工艺,发现由于粉末行为和工艺设计之间的不兼容,达到最大生产率平均超时2年,开发成本为估计的210%。在其间的几年里,植物工程技术得到了发展,但配方决策的合理化从来没有得到过比粗略的实证研究更多的研究。该项目建议开发一个虚拟配方实验室(VFL),这是一个用于预测和优化先进固体配方的可制造性和稳定性的软件工具。该团队已经在粉末流动、混合和压制方面建立了专业知识,这些专业知识将首次结合在一起,将配方变量与可制造性预测联系起来。该项目的总体目标是:(A)建立了解表面、颗粒结构和散体行为的科学基础,以解决加工和储存过程中的物理、化学和机械稳定性问题;(B)将这些纳入一个软件工具(VFL),该工具考虑到各种材料类型、颗粒结构和混合系统,使配方制作者能够在虚拟空间中测试配方变化的影响,并检查涵盖生产工厂中遇到的大多数制造困难的潜在问题。VFL的愿景是在该项目完成后的五年内,广泛应用于食品、药品和精细化学品中每一种新配方粉末产品的开发过程。VFL将考虑四个过程:粉末流动、混合、压实和储存;并将预测四个可制造性问题:流动/泛滥不良、分离/不均匀、粉末结块和压坯的强度/断裂。这些问题解决了固体颗粒材料加工中的大多数实际问题。该项目的总体目标是:(A)填补配方科学中的空白,将分子与可制造性联系起来,这将通过实验表征和数值模拟实现,以及(B)建立处理新材料的方法,以便虚拟实验室能够在不进行广泛的实验表征或数值模拟的情况下预测使用新材料的配方。这将通过根据上述调查的科学结果发展职能关系,同时确定这些关系的局限性和不确定性来实现。

项目成果

期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Correlations between segregation intensity and material properties such as particle sizes and adhesions and novel methods for assessment
  • DOI:
    10.1016/j.powtec.2021.04.023
  • 发表时间:
    2021-04-18
  • 期刊:
  • 影响因子:
    5.2
  • 作者:
    Deng, Tong;Garg, Vivek;Bradley, Michael S. A.
  • 通讯作者:
    Bradley, Michael S. A.
CLEAVING: a LAMMPS package to compute surface free energies
CLEAVING:用于计算表面自由能的 LAMMPS 软件包
A unified description of Surface Free Energy and Surface Stress
表面自由能和表面应力的统一描述
  • DOI:
    10.48550/arxiv.1911.02130
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Di Pasquale N
  • 通讯作者:
    Di Pasquale N
Unloading of elastoplastic spheres from large deformations
  • DOI:
    10.1016/j.powtec.2020.06.094
  • 发表时间:
    2020-09-01
  • 期刊:
  • 影响因子:
    5.2
  • 作者:
    Edmans, B. D.;Sinka, I. C.
  • 通讯作者:
    Sinka, I. C.
Numerical Determination of Contact Laws for Compressible Particles
可压缩颗粒接触定律的数值测定
  • DOI:
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Edmans B.
  • 通讯作者:
    Edmans B.
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