Functionalised optical fibre multiparameter sensing platform for monitoring during artificial ventilation

用于人工通气期间监测的功能化光纤多参数传感平台

• 批准号: EP/N025725/1
• 负责人: Serhiy Korposh
• 金额: $ 12.81万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FN025725%2F1
• 关键词: Functionalised; optical; fibre; multiparameter; sensing

Ventilator Associated Pneumonia (VAP) is a major health problem resulting in death, prolonged intensive care unit (ICU) stay and costs of >£nbn worldwide. Endotracheal tube colonization and biofilm formation play a key role in VAP. Maintenance of the respiratory function of mechanically ventilated patients requires adequate humidification, even in non-invasive ventilation in which inadequate humidification and heating of the inspired air has been associated with functional deterioration of nasal mucosa and can also lead to VAP. Thus, humidification and temperature are important factors of modern intensive care practice.At the present, there is no technology available to conduct in situ measurement of biofilm growth on an ETT or humidity and temperature of the artificial air delivered to the lungs.The project will exploit cutting edge sensing techniques based on an array of optical fibre long period gratings in order to produce a prototype multiparameter instrument for a clinical setting to reduce VAP risk, aid early diagnosis and guide treatment. Each sensing element of the optical fibre sensor array will be modified using an appropriate sensitive layer to achieve optimal response to the key parameters of the ETT, such as temperature, humidity and biofilm formation. Novel advanced materials such as molecular imprinting and mesoporous functional films will be utilised as sensitive layers. During the course of the project the device will be tested on clinical equipment, typically used in ICU, in a laboratory setting to demonstrate proof of concept to proceed to clinical studies. The proposal combines technology push with clinical pull and matches the aspirations of the "Optimising Treatment" Grand Challenge identified by EPSRC to address the optimisation of care through effective diagnosis, patient-specific prediction and evidence-based intervention. The proposal is multidisciplinary in nature combining expertise in photonics, chemistry and analytical science. The output and impact of the research will be maximised through the involvement of Dr Andy Norris at Nottingham University Hospitals Trust and the involvement of an ETT manufacturer (P3 Medical, a UK SME specialising in the manufacture of innovative, airway devices).

呼吸机相关性肺炎(VAP)是一个主要的健康问题，导致死亡、延长重症监护病房(ICU)的停留时间和全球范围内&gt；GB NBN的成本。气管内导管定植和生物被膜的形成在VAP中起着关键作用。维持机械通气患者的呼吸功能需要足够的湿化，即使在非侵入性通风中，吸入的空气不充分的湿化和加热已与鼻粘膜功能恶化相关，也可能导致VAP。因此，湿度和温度是现代重症监护实践中的重要因素。目前，还没有可用的技术来现场测量ETT上的生物膜生长或输送到肺部的人工空气的湿度和温度。该项目将利用基于光纤长周期光栅阵列的尖端传感技术，生产一种用于临床环境的多参数仪器原型，以降低VAP的风险，帮助早期诊断和指导治疗。光纤传感器阵列的每个传感元件将使用适当的敏感层进行修改，以实现对ETT的关键参数(如温度、湿度和生物膜形成)的最佳响应。新型先进材料如分子印迹和介孔功能薄膜将被用作敏感层。在项目过程中，该设备将在实验室环境中的临床设备上进行测试，通常用于ICU，以演示进行临床研究的概念证明。该提案将技术推动与临床拉动相结合，符合EPSRC确定的“优化治疗”大挑战的愿望，旨在通过有效的诊断、针对患者的预测和基于证据的干预来解决优化护理的问题。该提案涉及多个学科，融合了光子学、化学和分析科学方面的专业知识。这项研究的产出和影响将通过诺丁汉大学医院信托基金的安迪·诺里斯博士的参与和一家ETT制造商(P3 Medical，一家专门制造创新的呼吸道设备的英国中小企业)的参与来最大化。

项目成果

Optical fibre temperature sensor based on thermochromic liquid crystal

基于热致变色液晶的光纤温度传感器

• DOI: 10.1117/12.2539566
• 发表时间: 2019
• 作者: He C

A fiber-optic localized surface plasmon resonance (LSPR) sensor anchored with metal organic framework (HKUST-1) film for acetone sensing

• DOI: 10.1117/12.2539413
• 发表时间: 2019-08
• 作者: Liangliang Liu;Chenyang He;S. Morgan;R. Correia;S. Korposh

Multi-parameter measurements using optical fibre long period gratings for indoor air quality monitoring

• DOI: 10.1016/j.snb.2016.12.050
• 发表时间: 2017-06-01
• 期刊: SENSORS AND ACTUATORS B-CHEMICAL
• 影响因子: 8.4
• 作者: Hromadka, Jiri;Korposh, Sergiy;Tatam, Ralph P.
• 通讯作者: Tatam, Ralph P.

Polymeric optical fibre sensor coated by SiO2 nanoparticles for humidity sensing in the skin microenvironment

• DOI: 10.1016/j.snb.2017.07.191
• 发表时间: 2018-01-01
• 期刊: SENSORS AND ACTUATORS B-CHEMICAL
• 影响因子: 8.4
• 作者: Gomez, David;Morgan, Stephen P.;Korposh, Sergiy
• 通讯作者: Korposh, Sergiy

A reflection-mode fibre-optic sensor for breath carbon dioxide measurement in healthcare

用于医疗保健中呼吸二氧化碳测量的反射模式光纤传感器

• DOI: 10.1016/j.sbsr.2018.100254
• 发表时间: 2019-02-01
• 期刊: SENSING AND BIO-SENSING RESEARCH
• 影响因子: 5.3
• 作者: Liu, LiangLiang;Hao, FengHuan;Korposh, Serhiy
• 通讯作者: Korposh, Serhiy