Personalised nanomedicine for cancer therapy

用于癌症治疗的个性化纳米医学

• 批准号: EP/N026322/1
• 负责人: Giuseppe Battaglia
• 金额: $ 191.83万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FN026322%2F1
• 关键词: Personalised; nanomedicine; cancer; therapy

After decades of research, cancer is still one of the top killers responsible for almost 15% of the total death worldwide per year. One of the most critical limitation for cancer therapy is our inability to direct anticancer drugs to cancerous cells maximising killing and minimising side effects (often worse than the disease itself). This is due to the fact that cancer cells are the same healthy cells gone wrong and hence share many similarities with the good cells complicating detection and targeting. I propose here the engineering of ultra-small carriers (as small as a virus and 100 times smaller than cancer cells) that will be equipped with unique chemical signature to target almost exclusively cancer cells. These nanocarriers will also be able to carry a lot of drugs and deliver them right inside the cells where the drug is most effective. Once their job is done, the material that makes the carrier is dissolved into the same nutrients used by our body. Most importantly we will design nanocarriers using patient-derived tissues so to create a fully personalised targeting profile as well as a personalised drug dosage.

经过几十年的研究，癌症仍然是全球每年死亡总数的近15%的头号杀手之一。癌症治疗最关键的限制之一是我们无法将抗癌药物导向癌细胞，从而最大限度地杀死癌细胞并最小化副作用（通常比疾病本身更糟糕）。这是因为癌细胞是同样的健康细胞，因此与好细胞有许多相似之处，使检测和靶向变得复杂。我在这里提出了超小载体的工程设计（像病毒一样小，比癌细胞小100倍），它将配备独特的化学特征，几乎只针对癌细胞。这些纳米载体也将能够携带大量药物，并将它们输送到药物最有效的细胞内。一旦它们的工作完成，制造载体的材料就会溶解在我们身体所使用的相同营养物质中。最重要的是，我们将使用患者来源的组织设计纳米载体，以创建完全个性化的靶向配置文件以及个性化的药物剂量。

项目成果

On the design of precision nanomedicines

精密纳米药物的设计

• DOI: 10.26434/chemrxiv.5647969
• 发表时间: 2019
• 作者: Battaglia G

Bottom-Up Evolution of Vesicles from Disks to High-Genus Polymersomes.

• DOI: 10.1016/j.isci.2018.08.018
• 发表时间: 2018-09-28
• 期刊: iScience
• 影响因子: 5.8
• 作者: Contini C;Pearson R;Wang L;Messager L;Gaitzsch J;Rizzello L;Ruiz-Perez L;Battaglia G
• 通讯作者: Battaglia G

A Multiscale Study of Phosphorylcholine Driven Cellular Phenotypic Targeting.

磷酸胆碱驱动的细胞表型靶向的多尺度研究。

• DOI: 10.1021/acscentsci.2c00146
• 发表时间: 2022-07-27
• 期刊: ACS CENTRAL SCIENCE
• 影响因子: 18.2
• 作者: Acosta-Gutierrez, Silvia;Matias, Diana;Avila-Olias, Milagros;Gouveia, Virginia M.;Scarpa, Edoardo;Forth, Joe;Contini, Claudia;Duro-Castano, Aroa;Rizzello, Loris;Battaglia, Giuseppe
• 通讯作者: Battaglia, Giuseppe

One-Pot Synthesis of Oxidation-Sensitive Supramolecular Gels and Vesicles.

• DOI: 10.1021/acs.biomac.1c01039
• 发表时间: 2021-12-13
• 期刊: Biomacromolecules
• 影响因子: 6.2
• 作者: Duro-Castano A;Rodríguez-Arco L;Ruiz-Pérez L;De Pace C;Marchello G;Noble-Jesus C;Battaglia G
• 通讯作者: Battaglia G

Bottom-up Evolution from Disks to High-Genus Polymersomes

从盘到高属聚合物体的自下而上进化

• DOI: 10.26434/chemrxiv.6108467
• 发表时间: 2018
• 作者: Battaglia G