CATALYTIC ANTIBODIES FOR THERAPEUTIC APPLICATIONS

用于治疗应用的催化抗体

• 批准号: 3489755
• 负责人: Simon Williams
• 金额: $ 5万
• 依托单位: METABOLIX, INC.
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-04-15 至 1993-10-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3489755
• 关键词: abzyme; chemical cleavage; chemical synthesis; drug design /synthesis /production; enzyme linked immunosorbent assay; enzyme mechanism; haptens; hydrolysis; immunization; laboratory mouse; monoclonal antibody

The long term objectives of this research are to generate antibody catalysts for therapeutic applications. Specifically, we will prepare antibody catalysts to inactivate the AIDS virus and to deliver anti-tumor drugs to tumor sites for the treatment of cancer. Subsequent commercialization will include the development of therapies for other viral diseases and the preparation of detoxification agents. The therapeutic catalytic antibodies to antigens derived from these haptens. A new approach to the design of these haptens involves the use of aminophosphinic acids and is based on an analysis of enzyme mechanisms.

这项研究的长期目标是产生抗体 用于治疗应用的催化剂。 具体来说，我们将准备 抗体催化剂，以抑制艾滋病病毒并提供抗肿瘤 用于治疗癌症的药物。后续 商业化将包括为其他疾病开发治疗方法， 病毒性疾病和解毒剂的制备。 的 针对衍生自这些半抗原的抗原的治疗性催化抗体。 设计这些半抗原的一种新方法涉及使用 氨基膦酸，并基于酶机制的分析。