NEW BIOPOLYMERS FOR MEDICAL APPLICATIONS

用于医疗应用的新型生物聚合物

• 批准号: 3498980
• 负责人: Simon Williams
• 金额: $ 5万
• 依托单位: METABOLIX, INC.
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-04-01 至 1993-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3498980
• 关键词: Pseudomonas; acyltransferase; bacterial proteins; biomaterial development /preparation; biotransformation; chemical synthesis; copolymer; enzyme substrate; gas chromatography; molecular weight; nuclear magnetic resonance spectroscopy; polymerization; polymers; thioester

The long-term objectives of this research are to use a biological catalyst known as a polymerase, to create new biopolymers and identify those with useful properties for the biomedical industry. Specifically, in the biomedical area these novel biocompatible materials may be useful in applications such as: surgical aids as anti-adhesion agents; controlled drug delivery using microcapsules; wound care as sutures and gauzes; bone plates; and therapeutic targeting. The research goals involve preparing small organic molecules which may be converted, by the long chain polymerase from Pseudomonas oleovorans, into new biomaterials. The latter will subsequently be characterized. By screening a large number of small organic molecules it should be possible to create many new biodegradable polyesters for the medical industry.

这项研究的长期目标是使用生物 催化剂称为聚合酶，以创造新的生物聚合物， 具有生物医学工业有用性质的那些。 具体地说， 在生物医学领域，这些新的生物相容性材料可能是有用的， 在诸如以下应用中：作为抗粘连剂的外科辅助; 使用微胶囊的受控药物递送;作为缝合线的伤口护理， 纱布;骨板;和治疗靶向。 研究目标 涉及制备可通过以下方法转化的小有机分子： 长链聚合酶从假单胞菌oleovorans，到新的生物材料。 随后将对后者进行定性。 通过筛选大量 一些小的有机分子，它应该是可能的创造许多 用于医疗行业的新型生物降解聚酯。