NOVEL BIOPOLYMERS FOR THE MEDICAL INDUSTRY

用于医疗行业的新型生物聚合物

• 批准号: 2188602
• 负责人: Simon Williams
• 金额: $ 8.1万
• 依托单位: METABOLIX, INC.
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-04-01 至 1994-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2188602
• 关键词: Pseudomonadaceae; bacterial proteins; biomaterial development /preparation; coenzyme analog; enzyme activity; esterase; molecular weight; polyhydroxy compound; polymers; protein purification; protein structure function; thioester

A biological catalyst, known as a polymerase will be used to manufacture new biopolymers. The structure-property relationships of these polymers will be determined to identify which new materials may be useful in the biomedical industry. Specifically, in the biomedical area these novel biocompatable materials may be useful in applications such as: controlled drug delivery using microcapsules; nerve regeneration; wound care as sutures and gauzes, surgical aids as anti-adhesion agents; bone plates; and, therapeutic targeting. The research goals involve preparing small organic molecules which may be converted, by the short-chain polymerase from Zoogloea ramigera into new biomaterials. The latter will subsequently be characterized. By screening a range of small organic molecules it should be possible to create many new biodegradable polyesters for the medical industry.

一种被称为聚合酶的生物催化剂将用于生产