尿激酶特异性抑制剂作为抗转移剂-猫眼课题宝

尿激酶特异性抑制剂作为抗转移剂

批准号：

3492756

负责人：

HUGH H VARNER

金额：

$5.0万

依托单位：

BALTIMORE BIOTECH, INC.

依托单位国家：

美国

项目类别：

财政年份：

1991

资助国家：

美国

项目状态：

已结题

起止时间：

1991-09-15 至 1992-03-15

来源：

https://reporter.nih.gov/project-details/3492756

关键词：

amiloride antineoplastics combination cancer therapy disease /disorder model drug design /synthesis /production histopathology laboratory mouse melanoma metastasis neoplasm /cancer chemotherapy neoplastic cell plasminogen activator protease inhibitor pyrazines

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英文摘要

Urokinase-like plasminogen activator (uPA) has been implicated in tissue remodeling during such processes as tumor metastasis, wound healing and embryological development. Specific inhibitors of uPA have been developed which will be assayed as inhibitors of experimental metastasis in a mouse melanoma model system. Confirmation of a correlation between the uPA inhibitory and anti-metastatic properties of the compounds will be sought, as will information relating the inhibitors' structural features to their efficacy in vivo. The eventual outcome of confirmation of the efficacy of the drugs tested as anti-metastatic agents is intended to be the identification of a therapeutic agent or agents which will be useful in all cases of diagnosed solid tumors in humans as prophylaxis against metastasis.

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