RECOMBINANT CNTF FOR TREATMENT OF NEUROPHATHIES

用于治疗神经病的重组 CNTF

• 批准号: 3487947
• 负责人: BARBARA L CORDELL
• 金额: $ 5万
• 依托单位: CALIFORNIA BIOTECHNOLOGY, INC.
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-02-01 至 1991-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3487947
• 关键词: DNA replication; Escherichia coli; ciliary ganglion; complementary DNA; gene expression; genetic library; genetic manipulation; growth factor; messenger RNA; molecular cloning; nervous system disorder; neural degeneration; neurogenesis; neurotransmitter biosynthesis; nucleic acid sequence; parasympathetic nervous system; peptide hormone; peptide hormone metabolism; polymerase chain reaction; protein biosynthesis; protein purification; recombinant DNA; transfection

DESCRIPTION (Adapted from applicant's abstract): Ciliary Neurotrophic Factor (CNTF) is a potent polypeptide hormone whose actions appear to be restricted to the nervous system. CNTF has been observed to promote survival, parasympathetic neurotransmitter synthesis and neurite outgrowth in various sympathetic, sensory and parasympathetic neurons at femtomolar to low picomolar concentrations. Thus CNTF has potential clinical applications in the treatment of a number of different neuropathies and neurodegenerative disorders in man as well as in the treatment of traumatic nerve injury. It is the goal of this project to assess this potential by first providing a source of human CNTF using recombinant DNA methods (Phase I) and then using this source to establish efficacy in specific acute animal models of peripheral neuropathies (Phase II) and (if indicated) in human clinical trials (Phase III).

描述（改编自申请人摘要）：睫状神经营养 因子（CNTF）是一种有效的多肽激素，其作用似乎是 仅限于神经系统。 据观察， 存活、副交感神经递质合成和轴突生长 在各种交感神经元、感觉神经元和副交感神经元中， 到低皮摩尔浓度。 因此CNTF具有潜在的临床应用价值 用于治疗多种不同的神经病， 以及在治疗创伤性神经退行性疾病中的应用 神经损伤 本项目的目标是通过以下方式评估这种潜力： 首先使用重组DNA方法提供人CNTF的来源（阶段 I）然后使用该来源确定在特定急性 周围神经病动物模型（II期）和（如有指征） 人类临床试验（III期）。