A clinical trial of partially HLA-matched unrelated donor microtransplantation for prevention of relapse in patients with acute myeloid leukaemia ineligible for standard haemopoietic stem cell transplantation

部分 HLA 匹配的无关供体微移植预防不适合标准造血干细胞移植的急性髓系白血病患者复发的临床试验

• 批准号: nhmrc : 1061252
• 负责人: Prof David Gottlieb
• 金额: $ 10.32万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/clinical-trial-partially-cell-transplantation/454875
• 关键词: clinical; trial; partially; HLA; matched

Acute myeloid leukaemia has a poor prognosis in patients unable to undergo bone marrow transplant, in particular in the elderly. No proven therapy improves their poor outcome. There is an urgent need to identify clinically applicable, non-toxic therapies for this group of patients. We will perform a clinical trial of "microtransplantation" using unrelated stem cell donors in combination with chemotherapy to try to reduce the relapse rate in these patients without the toxic effects of standard stem cell transplantation.

急性髓性白血病在不能接受骨髓移植的患者中预后不良，特别是老年人。没有经过证实的治疗可以改善他们的不良结局。迫切需要为这组患者确定临床适用的无毒治疗方法。我们将进行一项“微移植”的临床试验，使用无关的干细胞供体与化疗相结合，试图降低这些患者的复发率，而没有标准干细胞移植的毒性作用。