COMBINED LASER-INDUCED HYPERTHERMIA/PDT SYSTEM

组合激光诱导热疗/PDT 系统

• 批准号: 3493218
• 负责人: DANIEL R DOIRON
• 金额: $ 5万
• 依托单位: PDT SYSTEMS
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-05-27 至 1993-11-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3493218
• 关键词: biomedical automation; biomedical equipment development; biosensor device; clinical biomedical equipment; combination cancer therapy; computer program /software; computer system design /evaluation; disease /disorder model; fiber optics; laboratory mouse; laser therapy; lasers; monitoring device; neoplasm /cancer photoradiation therapy; neoplasm /cancer thermotherapy; personal computers; radiation dosage; temperature

DESCRIPTION (Adapted from applicant's abstract): Photodynamic Therapy (PDT) using Photofrin is nearing regulatory approval both in the USA and abroad. It has been shown by a number of researchers that hyperthermia (HT), less than 45 degrees centrigrade, has a strong synergistic effect in combination with PDT. This synergism appears to be maximized when the HT is given concurrently with PDT instead of sequentially. It has also been shown that the local hyperthermia condition can be produced by a near infrared laser, Nd:YAG or AlGaAs diodes, through the same delivery systems used for PDT. This has been referred to as Laser Hyperthermia, or LHT. It is the objective of this application to develop an integrated LHT-PDT delivery system with a common computer-based control and monitoring system. The system will allow for use of pre-existing lasers, both HT and PDT, which are delivered to the system via fiberoptic cables. Each laser is to be individually controlled and combined into a single optical delivery fiber. The control system is to be based on a PC compatible computer and will provide active control of the LHT and PDT power levels, treatment intervals, monitoring and display of eight temperatures and four light intensity levels, tissue temperature stabilization, light dosimetry, and display the information in a user friendly manner. The emphasis in Phase I of the project is to develop the system, and to test it in an appropriate animal model.

描述（改编自申请人摘要）：光动力疗法 (PDT)使用Photofrin在美国和美国都接近监管批准， 国外 许多研究人员已经证明， (HT)，小于45度向心度，具有很强的协同作用， 结合PDT。 这种协同作用似乎是最大化时，HT 与PDT同时给予，而不是顺序给予。 还已经 表明局部高温条件可以由近 红外激光，Nd：YAG或AlGaAs二极管，通过相同的传输系统 用于PDT。 这被称为激光热疗或LHT。 它 本申请的目的是开发一种集成的LHT-PDT 该系统还包括一个具有通用计算机控制和监测系统的输送系统。 该系统将允许使用预先存在的激光，HT和PDT， 其通过光纤电缆传送到系统。 每个激光器都 单独控制并组合成单个光学递送 光纤 控制系统将基于PC兼容计算机， 将提供LHT和PDT功率水平的主动控制， 间隔，监测和显示八个温度和四个光 强度水平、组织温度稳定、光剂量测定和 以用户友好的方式显示信息。 第一阶段的重点 该项目的目的是开发该系统，并在适当的环境中对其进行测试。 动物模型