LASER INDUCED HYPERTHERMIA OF OCULAR TUMORS

激光诱导眼肿瘤热疗

• 批准号: 3497123
• 负责人: DANIEL R DOIRON
• 金额: $ 5万
• 依托单位: PDT SYSTEMS
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-03-18 至 1991-09-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3497123
• 关键词: disease /disorder model; eye laser surgery; eye neoplasms; hyperthermia therapy; laboratory rabbit; neoplasm /cancer thermotherapy; neoplasm /cancer transplantation; user protection

DESCRIPTION: (Investigator's Abstract) Intraocular hyperthermia, IHT, is being investigated as an adjunct to ionizing radiation therapy as a means of improving therapeutic response while minimizing undesired side effects. For microwave, radio frequency or ultrasound inducing IHT it has been difficult to localize such heating to the tumor tissue. It is proposed to develop a system for intraocular laser induced hyperthermia, ILHT. Emphasis in Phase-I is to develop the necessary delivery systems and testing of them in an appropriate animal model. The system is to include both a transcorneal approach and a transcleral approach. The laser to be used is the 1064nm NdYAG due to its deep penetration in tissue. The delivery systems will emphasis the ability to irradiate a large area >1.0 cm in diameter, with uniform irradiance. Testing is to be done in rabbits with and without transplanted choroidal tumors. Testing in phase-I will include on line thermal monitoring in the animal systems along with thermal modeling of the response. Limited results to date by Gomer and Svaasand, with crude delivery devices, have been promising. If the proper delivery devices and overall system can be developed ILHT could find a significant use in the management of intraocular tumors in combination with other therapies. Its commercial potential could be significant if it can be made cost effective and easy to use, which is the specific aim of this proposal.

描述：（研究者摘要）眼内高热，IHT，是 作为电离辐射治疗的辅助手段， 改善治疗反应，同时最大限度地减少不良副作用。 对于微波、射频或超声诱导的IHT， 很难将这种加热定位到肿瘤组织。 提出要 研制了一种眼内激光诱导热疗系统。 第一阶段的重点是开发必要的运载系统， 在适当的动物模型中测试它们。 该系统将包括 经角膜途径和经巩膜途径。 该激光器将 使用的是1064nm NdYAG，因为其在组织中的深度穿透。 的 发射系统将强调照射大于1.0的大面积的能力 直径1.0cm，辐照度均匀。 试验将在兔子中进行 有和没有移植脉络膜肿瘤。 第一阶段的测试将 包括动物系统中的在线热监测沿着 响应的建模。 Gomer和Svaasand迄今为止的结果有限， 与原油输送装置相结合，已经很有希望了。 如果正确的交付 设备和整个系统可以开发ILHT可以找到一个显着的 与其他药物联合用于眼内肿瘤的治疗 治疗 如果能够制造出它， 成本有效且易于使用，这是该提议的具体目标。