CCD CAMERA SYSTEM FOR X-RAY DIFFRACTION IMAGING

这是一个研究新的2048x2048像素的优点的建议 CCD型固态图像传感器在X射线衍射中的应用 生物大分子在拟议的实验中，CCD将 直接光学耦合到X射线敏感荧光屏的光纤， 消除了通常在这种X射线中使用的图像增强器 衍射成像设备这导致了实质性的改善 空间分辨率和动态范围。已作好安排 在Sol Gruner教授的X射线衍射中测试CCD成像系统 普林斯顿大学物理系实验室。普林斯顿 Scientific Instruments拥有2048x2048像素CCD摄像系统， 将被用于这些实验。该项目将支持设计 制作安装CCD和光纤荧光粉的夹具， 一起筛选并进行实验和分析数据。 拟议的第一阶段计划是一个具有成本效益的方式来调查 这些新的图像传感器的优势，X射线衍射相关 research.这种CCD成像的高分辨率和宽动态范围 该系统特别适合于X射线劳厄问题 用同步加速器产生的蛋白质晶体衍射 多色X射线和蛋白质衍射从大单位细胞， 第二阶段项目。

This is a proposal to investigate the advantages of a new 2048x2048 pixel CCD type solid state image sensor for X-ray diffraction applications on biological macromolecules. In the proposed experiments the CCD will be fiber optically coupled directly to an X-ray sensitive phosphor screen, eliminating the image intensifier normally employed in such X-ray diffraction imaging equipment. This results in a substantial improvement in spatial resolution and dynamic range. Arrangements have been made to test the CCD imaging system in Prof. Sol Gruner's X-ray diffraction laboratory in Princeton University, Department of Physics. Princeton Scientific Instruments has the 2048x2048 pixel CCD camera system which would be used for these experiments. This grant would support designing and building the fixture for mounting the CCD and fiber optics phosphor screen together and conducting the experiments and analyzing the data. The proposed Phase I program is a cost effective way to investigate the advantages of these new image sensors to X-ray diffraction related research. The high resolution and wide dynamic range of this CCD imaging system is particularly well matched to the problem of X-ray Laue diffraction from protein crystals using synchrotron generated polychromatic X-rays and protein diffraction from large unit cells, a Phase II project.