2D Materials for Next Generation Healthcare Technologies (2D-Health)

用于下一代医疗技术的 2D 材料 (2D-Health)

• 批准号: EP/P00119X/1
• 负责人: Kostas Kostarelos
• 金额: $ 678.88万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FP00119X%2F1
• 关键词: 2D; Materials; Next; Generation; Healthcare

This Programme Grant capitalise on the world-leading expertise and research infrastructure on graphene and 2D materials available at the University of Manchester (UoM) to develop future therapies and generate innovative healthcare technology platforms by ascertaining UK leadership in biotech and pharmaceutical development.There is an increasing need to develop new innovative technologies for healthcare, digital services and other innovation with the vision to deliver health services in more efficient ways and with benefits to patients and taxpayers. The National Health Services (NHS) is under increasing financial pressure in recent years, mainly due to population growth and an increased demand on NHS services. In addition to that, a growing ageing population associated with increased prevalence of pathologies such as cardiovascular disease, dementias, cancer and diabetes significantly add to the cost of care in the NHS. Innovative solutions for development of future therapies that could respond to such unmet clinical needs, reduce the cost burden on the NHS and provide a more effective, safer and patient-centred care is highly needed now. 2D materials are one atom thick materials. The family of these flat crystals is very large and includes transition metal dichalcogenides, hexagonal boron nitride, and graphene among many others. Altogether, they cover a large range of properties (from conductive to insulating, from transparent to opaque, from mechanically stiff to compliant) that can be exploited for the creation of new devices and technologies with a wide range of applications. Various innovative G2D based materials and technologies have been pioneered at the University of Manchester such as the super-hydrophilic graphene oxide based membranes, 2D material water based inks for printable electronics, and graphene based printed technology for wireless wearable communication applications. These newly developed materials and technologies have great potential for use in biomedicine can be exploited for the design and engineering of novel healthcare technologies towards solutions or improvements of unmet clinical needs.In the 2D-Health research programme, we formed a team of internationally renowned and highly esteemed multi-disciplinary researchers and some of the world-leaders in G2D research in order to utilise selected unique properties offered by G2D materials and technologies and to develop innovative solutions for specific unmet clinical needs in wound care and management (relevant to diabetes); tissue rehabilitation by electrical stimulation (relevant to dementia); cell therapeutics (relevant to cardiovascular disease); and immunotherapeutics (relevant to cancer).This programme directly aligns to the EPSRC Healthcare Technologies priorities by aiming to develop future therapies in specific applications of unmet clinical need and draws on several cross-cutting capabilities: a) custom-design G2D materials into advanced materials under specifications aimed at a precise industry-driven use, exploring different chemical modification strategies; b) development of novel imaging and sensing technologies for tracking and monitoring therapeutic intervention; and c) develop G2D-based technologies through the preclinical stage for each of the application areas using relevant cellular and animal models. Strong partnership with industrial partners for rapid clinical translation and in collaboration with ethicists and regulators aims to ensure responsible and societally-acceptable innovations.

该项目资助利用曼彻斯特大学（UoM）在石墨烯和二维材料方面的世界领先的专业知识和研究基础设施，通过确定英国在生物技术和制药开发方面的领导地位，开发未来的疗法，并产生创新的医疗技术平台。越来越需要为医疗保健、数字服务和其他创新开发新的创新技术，以期以更有效的方式提供卫生服务，并使患者和纳税人受益。国民保健服务近年来面临越来越大的财政压力，主要是由于人口增长和对国民保健服务的需求增加。除此之外，随着心血管疾病、痴呆、癌症和糖尿病等疾病的流行，人口老龄化的加剧大大增加了国民保健服务的费用。现在迫切需要创新的解决方案来开发未来的治疗方法，以应对这些未满足的临床需求，减少NHS的成本负担，并提供更有效、更安全、以患者为中心的护理。二维材料是一种原子厚度的材料。这些扁平晶体家族非常庞大，包括过渡金属二硫族化合物、六方氮化硼和石墨烯等。总的来说，它们涵盖了广泛的特性（从导电到绝缘，从透明到不透明，从机械硬度到柔顺），可以用于创建具有广泛应用的新设备和技术。曼彻斯特大学开创了各种创新的基于G2D的材料和技术，如超亲水性氧化石墨烯基膜，用于可印刷电子产品的2D材料水性油墨，以及用于无线可穿戴通信应用的基于石墨烯的印刷技术。这些新开发的材料和技术在生物医学领域具有巨大的应用潜力，可以用于设计和开发新的医疗保健技术，以解决或改善未满足的临床需求。在2D-Health研究项目中，我们组建了一个由国际知名和备受尊敬的多学科研究人员和一些世界领先的G2D研究人员组成的团队，以利用G2D材料和技术提供的选定的独特特性，并为伤口护理和管理（与糖尿病相关）的特定未满足的临床需求开发创新解决方案；电刺激组织康复（与痴呆相关）；细胞疗法（与心血管疾病相关）；免疫疗法（与癌症相关）。该项目旨在开发未满足临床需求的特定应用的未来疗法，并利用几个交叉能力，直接与EPSRC医疗技术优先事项保持一致：a)定制设计G2D材料，根据旨在精确行业驱动使用的规格，开发先进材料，探索不同的化学改性策略；B)开发用于跟踪和监测治疗干预的新型成像和传感技术；c)利用相关的细胞和动物模型，通过临床前阶段为每个应用领域开发基于g2d的技术。与快速临床转化的工业伙伴建立强有力的伙伴关系，并与伦理学家和监管机构合作，旨在确保负责任和社会可接受的创新。

项目成果

Self-Induced Mode-Locking in Electrically Pumped Far-Infrared Random Lasers.

• DOI: 10.1002/advs.202206824
• 发表时间: 2023-03
• 期刊: ADVANCED SCIENCE
• 影响因子: 15.1
• 作者: Di Gaspare, Alessandra;Pistore, Valentino;Riccardi, Elisa;Pogna, Eva A. A.;Beere, Harvey E.;Ritchie, David A.;Li, Lianhe;Davies, Alexander Giles;Linfield, Edmund H.;Ferrari, Andrea C.;Vitiello, Miriam S.
• 通讯作者: Vitiello, Miriam S.

2245P Graphene oxide: A promising platform for delivery of cancer immunotherapy

2245P 氧化石墨烯：一个有前景的癌症免疫治疗平台

• DOI: 10.1016/j.annonc.2023.09.1273
• 发表时间: 2023
• 期刊: Annals of Oncology
• 影响因子: 50.5
• 作者: Chattrakarn S

Abstract LB334: Assessment of the potential of graphene oxide as an antigen delivery platform for cancer immunotherapy

摘要 LB334：评估氧化石墨烯作为癌症免疫治疗抗原递送平台的潜力

• DOI: 10.1158/1538-7445.am2023-lb334
• 发表时间: 2023
• 期刊: Cancer Research
• 影响因子: 11.2
• 作者: Chattrakarn S

Deep Tissue Translocation of Graphene Oxide Sheets in Human Glioblastoma 3D Spheroids and an Orthotopic Xenograft Model

• DOI: 10.1002/adtp.202000109
• 发表时间: 2020-10-09
• 期刊: ADVANCED THERAPEUTICS
• 影响因子: 4.6
• 作者: de Lazaro, Irene;Sharp, Paul;Kostarelos, Kostas
• 通讯作者: Kostarelos, Kostas

Graphene-black phosphorus printed photodetectors

• DOI: 10.1088/2053-1583/acc74c
• 发表时间: 2023-07-01
• 期刊: 2D MATERIALS
• 影响因子: 5.5
• 作者: Akhavan, S.;Ruocco, A.;Ferrari, A. C.
• 通讯作者: Ferrari, A. C.