NOVEL CLASS OF FLUOROCARBONS AS BLOOD SUBSTITUTES

作为血液替代品的新型氟碳化合物

• 批准号: 3501491
• 负责人: GORDHAN N PATEL
• 金额: $ 4.99万
• 依托单位: JP LABORATORIES, INC.
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-01 至 1990-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3501491
• 关键词: blood /plasma substitute; chemical synthesis; glycerophosphorylcholine; laboratory mouse; respiratory oxygenation

A novel class of fluorochemical are proposed as blood substitutes. The proposed compositions will be synthesized, purified, and characterized. Emulsions and other preparations will be prepared and their ability to dissolve oxygen will be determined. The efficacy of the proposed fluorochemicals as blood substitute will be determined using mice. It is expected that some of the proposed fluorochemicals would prevent clearance of the particles by the reticulolendotential system.

一种新的含氟化合物被提议作为血液代用品。 的 将合成、纯化和表征所提出的组合物。 将制备乳液和其他制剂，并且它们能够 将测定溶解氧。 建议的有效性 将使用小鼠来确定作为血液替代物的氟化合物。 是 预计一些拟议中的含氟化合物将阻止清除 由网状内皮系统控制。