NOVEL CLASS OF FLUOROCARBONS AS BLOOD SUBSTITUTES

作为血液替代品的新型氟碳化合物

• 批准号: 3508701
• 负责人: GORDHAN N PATEL
• 金额: $ 25.35万
• 依托单位: JP LABORATORIES, INC.
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-01 至 1995-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3508701
• 关键词: blood /plasma substitute; blood chemistry; chemical stability; chemical structure; drug design /synthesis /production; drug screening /evaluation; emulsions; fluorohydrocarbon; fluosol; gas chromatography; hemoglobin; laboratory mouse; laboratory rabbit; laboratory rat; lipid solubility; liposomes; oxygen transport; phospholipids; tissue /cell culture; toxicology; viscosity; water solubility

A novel class of fluorocarbons are proposed as blood substitutes. The proposed compounds will be synthesized, purified and characterized. Emulsions and other preparations will be made and their ability to dissolve oxygen will be determined. A few fluorocarbons which are nontoxic will be synthesized in larger quantity. The efficacy of selected fluorocarbons will be determined using small animals.

一类新的氟碳化合物被提出作为血液替代品。这个 拟合成的化合物将被合成、提纯和表征。 乳剂和其他制剂将被制成，它们有能力 溶解氧将被测定。一些氟碳化合物，它们是 无毒的将被大量合成。精选的功效 氟碳化合物将使用小动物进行测定。