ENHANCEMENT OF OSSEOINTEGRATION USING RESONANT EM FIELDS

使用共振电磁场增强骨整合

• 批准号: 3495159
• 负责人: ALLAN M WEINSTEIN
• 金额: $ 5万
• 依托单位: CAPSTONE THERAPEUTICS CORPORATION
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-03-01 至 1990-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3495159
• 关键词: biological models; chemical bond resonance; dental implants; dogs; ion transport; magnetic field; membrane permeability; osteogenesis

At a (June 1988) NIH Consensus Development Conference on Dental Implants, it was reported that, during the period 1983 to 1987, the number of dental implants inserted in the U.S. increased fourfold and the number of practitioners performing implants increased tenfold. Furthermore, it was estimated that 300,000 or more dental implants will be used in the U.S. by 1992. Osseointegration, particularly in two stage root form implants, has been shown to result in excellent performance of dental implants. However, achieving osseointegration often requires extensive periods of time (one year) with the implant out of function. With early functional restoration, osseointegration is often never achieved. The long term objective of this work is to develop a non-invasive treatment modality that can be used to enhance osseointegration by either reducing the time to achieve it or by providing predictable bone augmentation. The aim of this study is to demonstrate the feasibility of utilizing resonant electromagnetic fields to stimulate osteogenesis and thereby enhance dental implant osseointegration. Using a canine transcortical model, animals will be placed in aligned static and time varying magnetic fields for periods of three and six weeks. While it would be preferable to utilize an edentulous mandible model, given the time and budgeting constraints the transcortical model is more appropriate for demonstration of feasibility. The conditions on the field will be set to stimulate the transport across cell membranes of specific ions. The osseointegration potential of the resonant electromagnetic field treatment will be studied utilizing attachment strength and histology of the interface in the treated limbs as compared to the untreated control limbs.

在1988年6月举行的NIH牙科植入物共识发展会议上， 据报道，在1983年至1987年期间， 在美国植入的植入物增加了四倍， 从事植入手术的医生增加了十倍。 而且还是 据估计，30万或更多的牙科植入物将在美国使用， 1992. 骨整合，特别是在两阶段根形种植体中， 已被证明导致牙科植入物的优异性能。 然而，在这方面， 实现骨整合通常需要长时间（一个 年），植入物失效。 随着早期功能恢复， 骨结合常常无法实现。 这一长期目标 我们的工作是开发一种非侵入性的治疗方式， 通过减少实现骨整合的时间或 提供可预测的骨增量。 本研究的目的是 证明了利用谐振电磁场的可行性， 刺激骨生成，从而增强牙植入物骨结合。 使用犬经皮质模型，将动物放置在对齐的 静态和随时间变化的磁场持续三周和六周。 虽然最好使用无牙下颌骨模型， 时间和预算的限制，经皮层模型是更多 适合论证可行性。 球场上的情况 将被设置为刺激特定的跨细胞膜运输， 离子。 共振电磁场的骨整合潜力 治疗将利用附着强度和组织学进行研究， 与未处理对照相比，处理肢体中的界面 四肢