IN VIVO COINCIDENCE XRF MEASUREMENTS FOR HEAVY METALS

体内重金属符合 XRF 测量

• 批准号: 3496633
• 负责人: DOUGLAS E BURGER
• 金额: $ 4.95万
• 依托单位: ABIOMED, INC.
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-03-01 至 1991-03-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3496633
• 关键词: X ray; child (0-11); clinical biomedical equipment; fluorescence; lead; lead poisoning; mercury; mercury poisoning

X-ray fluorescence (XRF) is the most precise method of measuring body and organ burdens of heavy metals in vivo. However, the required precision for screening of chronically, low-level exposed populations for these metals, in particular lead and mercury, is between 5 and 20 times greater than achievable by current methods. This proposal describes an innovative variation of XRF which can provide an improvement in precision of one to two orders of magnitude over present technology. This is achieved by reducing the background under the signal by a factor of 10 million, while reducing the signal itself by only 100. Phase I will prove the feasibility of the approach. Three to four million young children from all levels of society are exposed to environmental sources of lead at concentrations that place them at risk of adverse health effects. The investigation of mercury is ubiquitous since many foods, and especially seafoods, contain significant amounts of mercury. There are over 100 independent occupations with possible exposures to lead or mercury. Yet, there is no tool available to measure body or organ burdens of lead or mercury with sufficient precision for screening chronically, low-level exposed populations. The proposed approach will enable the development of such a tool.

X射线荧光（XRF）是测量物体的最精确的方法， 体内重金属的器官负荷。 然而，所需的精度 对长期低水平接触这些金属的人群进行筛查， 特别是铅和汞的含量是其5至20倍 通过现有的方法。 该提案描述了一种创新的 XRF的一种变化，它可以提供一个精度的改进， 比现有技术高出两个数量级 这是通过 将信号下的背景降低1000万倍， 使信号本身仅减少100。 第一阶段将证明可行性 的方法。 来自社会各阶层的三到四百万儿童受到影响， 环境来源的铅浓度，使他们处于危险之中 对健康的不良影响。 对汞的调查无处不在 因为许多食物，尤其是海鲜，含有大量的 汞 有超过100个独立的职业， 接触铅或汞。 然而，没有可用的工具来衡量 身体或器官的铅或汞负荷，并具有足够的精确度， 筛查长期低水平接触人群。 拟议 这种方法将有助于开发这样一种工具。