OPTIMIZATION OF A RESPONSIVE CLINICAL PERFUSION MONITOR

响应式临床灌注监测仪的优化

• 批准号: 3508554
• 负责人: WILLIAM NEWMAN
• 金额: $ 18.64万
• 依托单位: THERMAL TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-01 至 1991-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3508554
• 关键词: blood flow measurement; clinical biomedical equipment; computer program /software; laboratory rat; patient monitoring device; perfusion; thermal blood flow measurement

Tissue blood flow is one of the most important physiologic parameters and also one of the most difficult to measure. The research proposed in this Phase II grant builds on the results on the Phase I feasibility study in the continued development of an integrated measurement system to provide both high precision, quantitative measurements of the local perfusion level, and rapid, real-time monitoring of transient perfusion variations. Recognizing that the thermal transducer is the fundamental determinant of ultimate measurement capabilities, the Phase I project addressed the design, fabrication and evaluation of a sensitive and linear thermal transducer as the basis of a clinical instrument for the measurement and monitoring of tissue thermal properties, including perfusion. These results will be more fully implemented in Phase II, where the thermal transducer will be integrated into the measurement instrumentation system to form the basis of an innovative and powerful measurement technique, with a projected ability to quantify perfusion to levels below 10 mi/100 gm-min and perfusion variations as small as 1-2 mi/100 gm-min. This will be followed by in vitro laboratory testing and evaluation, and later by clinical testing in several participating research laboratories in the Boston area. the results of this extensive development and refinement effort are expected to lead to a product of significant versatility and commercial potential.

组织血流量是最重要的生理参数之一， 也是最难测量的。这项研究提出， 第二阶段拨款是根据第一阶段可行性研究的结果， 继续开发综合测量系统， 局部灌注的高精度定量测量 水平和快速实时监测瞬时灌注变化。 认识到热传感器是 最终的测量能力，第一阶段项目解决了 敏感线性热成像仪的设计、制造和评估 传感器作为临床测量仪器的基础， 监测组织热特性，包括灌注。这些 结果将在第二阶段得到更充分的实施， 传感器将被集成到测量仪器系统中 形成创新和强大的测量技术的基础， 具有将灌注量化到低于10 mi/100的水平的预计能力 gm-min和灌注变化小至1-2 mi/100 gm-min。 随后进行体外实验室测试和评价，随后进行 在几个参与的研究实验室进行临床试验， 波士顿地区。这种广泛的发展和完善的结果 预计这些努力将导致一种具有显著多功能性的产品， 商业潜力。