QUANTIFICATION OF HYPERTHERMIA PRETREATMENT PROTOCOL

热疗预处理方案的量化

• 批准号: 3506782
• 负责人: WILLIAM NEWMAN
• 金额: $ 24.89万
• 依托单位: THERMAL TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-12-01 至 1994-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3506782
• 关键词: bioengineering /biomedical engineering; biosensor device; computer program /software; computer system design /evaluation; hyperthermia therapy; mathematical model; method development; neoplasm /cancer thermotherapy; patient care planning; perfusion; temperature

DESCRIPTION (Adapted from Applicant's Abstract): This project addresses the development of a quantitative hyperthermia therapy planning protocol. Empirical and analytical models are used to relate local temperature rise and SAR (specific absorption rate) to measurements of local tissue perfusion and thermal properties obtained prior to and during patient hyperthermia therapy. Phase I research confirmed the relation (termed the applicator "characteristic heating curve") between the local rate of thermal dissipation and the ratio of steady-state temperature rise to SAR to each point in the treatment volume. The theoretical work and the experimental results of Phase I further showed that local tissue perfusion is the critical determinant for the ratio delta T to SAR. Phase II will address the continued development of this effort, resulting in a convenient and easily applied therapy planning protocol. Tasks to be undertaken in Phase II include hardware and software development to support each of the required measured parameters (perfusion, thermal properties, temperature and SAR) at multiple tissue sites within a treatment volume. This will be followed by validation and evaluation in controlled experiments by Thermal Technologies in collaboration with our clinical collaborators. In the clinical setting, these characteristic heating curves, combined with pre-treatment measurements of tissue perfusion and thermal properties, can predict the ability to achieve therapeutic heating, or whether excessive heating of intervening tissues is likely to be treatment-limiting. This will be of immediate benefit to hyperthermia therapy: a standard measure of tissue thermal clearance will enable objective comparison and evaluation of applicators and modalities; the spatial distribution of perfusion can be used as a quantitative basis for tailoring the SAR distribution to the tumor; and clearly untreatable regions can be identified to provide the rationale for canceling therapy, for a change of applicator or modality, or for subsequent treatment with a more appropriate applicator.

描述(改编自申请者摘要)：本项目 介绍了一种定量热疗疗法的发展 规划方案。经验模型和分析模型用于 将局部温升和比吸收率(SAR) 局部组织灌注和热物性的测量 在患者热疗前和热疗期间获得。阶段 我的研究证实了这种关系(称为施肥者 “特性加热曲线”)在局部升温速率之间 耗散和稳态温升与合成孔径雷达的比率 至治疗体积中的每个点。理论工作和 第一阶段的实验结果进一步表明，局部 组织灌注度是比值T的关键决定因素 转到特区。第二阶段将解决这一问题的持续发展。 努力，结果是一种方便和容易应用的治疗方法 规划方案。第二阶段将进行的任务包括 硬件和软件开发以支持所需的每一个 测量的参数(灌流、热物性、温度和 在处理体积内的多个组织部位。这将是 随后在对照实验中进行验证和评估 由热技术公司与我们的临床合作 合作者。在临床环境中，这些特征 加热曲线，结合组织的前处理测量 灌注和热物性，可以预测能力 达到治疗性加热，还是过热 干预组织很可能是治疗受限的。这将是 对热疗有立竿见影的效果：标准措施 组织热清晰度将使客观比较和 对施用者和方式的评价；空间分布 可作为量身定做 肿瘤的SAR分布；以及明显无法治疗的区域可以 被确定为取消治疗的理由， 更换敷贴器或方式，或进行后续治疗 使用更合适的涂抹器。