QUANTIFICATION OF HYPERTHERMIA PRETREATMENT PROTOCOL

本项目致力于发展一种定量热疗 治疗计划协议。 初步实验表明， 稳态温升与SAR的比值之间存在关系 和有效的组织热导率（其解释了由于 传导和血液流动）。 然而，没有可用的方法 用于评估治疗中的热耗散机制 音量. 这项开发工作将侧重于改进测量 应用于超声和 微波热疗输送系统 增强的能力 热扩散探头将被扩展，以测量 多个组织部位的温度、热导率和SAR 通过开发多传感器和导管传感器实现治疗体积 probes. “特征加热曲线”，涉及有效热 局部组织加热的传导性，将开发用于一系列 哈佛-麻省理工学院热疗中心和 达纳·法伯癌症研究所。 在临床环境中，这些曲线， 结合有效导热率的预处理测量， 可以预测实现治疗加热的能力，或者是否 介入组织的过度加热很可能是治疗- 限制。 这将对热疗有直接的好处： 组织热清除标准测量将使得能够客观地 施用器和模式的比较和评价;空间 有效导热系数的分布可用作 用于针对肿瘤定制SAR分布的定量基础;以及 可以确定明显无法治疗的区域， 取消治疗，改变施源器或模态，或 随后用更合适的涂抹器进行治疗。

This project addresses the development of a quantitative hyperthermia therapy planning protocol. Preliminary experiments show that a distinctive relation exists between the ratio of steady-state temperature rise to SAR and effective tissue thermal conductivity (which accounts for heat loss due to both conduction and blood flow). However, there is no available method for assessing the thermal dissipative mechanisms within the treatment volume. This development effort will focus on improving measurement instrumentation and methodology for application to both ultrasound and microwave hyperthermia delivery systems. The capabilities of the Enhanced Thermal Diffusion Probe will be extended to yield measurements of temperature, thermal conductivity, and SAR at multiple tissue sites within a treatment volume through development of Multi-Sensor and Catheter Sensor probes. "Characteristic heating curves," relating effective thermal conductivity to local tissue heating, will be developed for a range of hyperthermia applicators at the Harvard-MIT Hyperthermia Center and the Dana Farber Cancer Institute. In the clinical setting, these curves, combined with pre-treatment measurements of effective thermal conductivity, can predict the ability to achieve therapeutic heating, or whether excessive heating of intervening tissues is likely to be treatment- limiting. This will be of immediate benefit to hyperthermia therapy: a standard measure of tissue thermal clearance will enable objective comparison and evaluation of applicators and modalities; the spatial distribution of effective thermal conductivity can be used as a quantitative basis for tailoring the SAR distribution to the tumor; and clearly untreatable regions can be identified to provide the rationale for canceling therapy, for a change of applicator or modality, or for subsequent treatment with a more appropriate applicator.