AUDITORY BRAINSTEM RESPONSE AT HIGH STIMULUS RATES

高刺激率下的听觉脑干反应

• 批准号: 3507158
• 负责人: BARBARA SILVERBERG
• 金额: $ 19.96万
• 依托单位: ABRATECH CORPORATION
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-01-01 至 1993-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3507158
• 关键词: auditory stimulus; brain stem; computer assisted diagnosis; diagnosis quality /standard; hearing tests; mathematics; stimulus /response

DESCRIPTION: (Adapted from the Applicant's Abstract.) The goal of this research is to continue the implementation and testing of an algorithm that permits the accurate recording of the Auditory Brainstem Response (ABR) at very high repetition rates. In Phase I, it was shown that, through the use of this algorithm, it was possible to record averaged ABRs to click stimuli in anesthetized cats at repetition rates as high as 500 Hz, and to reconstruct the first 10ms of the ABR even though the stimuli were spaced only 2 ms apart and the ABRs overlapped one another. In Phase II the algorithm will be tested in ABR recordings in humans. Using a computer which records the A-D values from every sweep directly on the computer's hard disk will permit the efficacy of different analysis algorithms to be analyzed using identical data. Similarly, the same data will be digitally filtered and then re-analyzed using different sets of filter characteristics, rather than pre-filtering the data prior to averaging, as was done in Phase I. Using the data obtained, the authors will design a clinical testing procedure making use of this algorithm. The improved method of recording the ABR will increase the sensitivity of ABR testing in a wide variety of diseases, including HIV infection and AIDS.

描述：（改编自申请人的摘要。）这个目标 研究的目的是继续实现和测试一种算法， 允许准确记录听觉脑干反应（ABR）， 非常高的重复率。 在第一阶段，通过使用 这种算法，它是可能的，记录平均ABR的点击刺激 重复频率高达500 Hz， 重建ABR的前10 ms，即使刺激是间隔的 间隔仅2 ms，ABR彼此重叠。 在第二阶段， 算法将在人类ABR记录中进行测试。 使用计算机 它将每次扫描的A-D值直接记录在计算机的 硬盘将允许不同的分析算法的功效， 使用相同的数据进行分析。 同样，同样的数据也会被数字化， 过滤，然后使用不同的过滤器组重新分析 特性，而不是在平均之前对数据进行预滤波，如 是在第一阶段完成的利用获得的数据，作者将设计一个 临床测试程序使用该算法。 改进的 记录ABR的方法将增加ABR测试的敏感性， 各种各样的疾病，包括艾滋病毒感染和艾滋病。