AUDITORY BRAINSTEM RESPONSE AT HIGH STIMULUS RATES

描述：(改编自申请人的摘要。)这样做的目的是 研究是继续实现和测试一种算法，该算法 允许准确记录听觉脑干反应(ABR) 重复率非常高。在第一阶段，通过使用 在该算法中，可以记录点击刺激的平均ABR 在麻醉猫体内，重复频率高达500赫兹，并 重建ABR的前10ms，即使刺激是间隔的 相隔仅2毫秒，ABR彼此重叠。在第二阶段 该算法将在人体的ABR录音中进行测试。使用计算机 它将每次扫描的A-D值直接记录在计算机的 硬盘将允许不同分析算法的效率 使用相同的数据进行分析。同样，同样的数据也将被数字化 使用不同的过滤器组进行过滤，然后重新分析 特征，而不是在平均之前对数据进行预过滤，如 是在第一阶段完成的，作者将使用获得的数据设计一个 使用该算法的临床测试程序。改进后的 记录ABR的方法将提高ABR测试的敏感性 各种各样的疾病，包括艾滋病毒感染和艾滋病。

DESCRIPTION: (Adapted from the Applicant's Abstract.) The goal of this research is to continue the implementation and testing of an algorithm that permits the accurate recording of the Auditory Brainstem Response (ABR) at very high repetition rates. In Phase I, it was shown that, through the use of this algorithm, it was possible to record averaged ABRs to click stimuli in anesthetized cats at repetition rates as high as 500 Hz, and to reconstruct the first 10ms of the ABR even though the stimuli were spaced only 2 ms apart and the ABRs overlapped one another. In Phase II the algorithm will be tested in ABR recordings in humans. Using a computer which records the A-D values from every sweep directly on the computer's hard disk will permit the efficacy of different analysis algorithms to be analyzed using identical data. Similarly, the same data will be digitally filtered and then re-analyzed using different sets of filter characteristics, rather than pre-filtering the data prior to averaging, as was done in Phase I. Using the data obtained, the authors will design a clinical testing procedure making use of this algorithm. The improved method of recording the ABR will increase the sensitivity of ABR testing in a wide variety of diseases, including HIV infection and AIDS.