STIMULUS-PAIRS--THREE-D AUDITORY BRAINSTEM RESPONSE

刺激对--三维听觉脑干反应

• 批准号: 3504114
• 负责人: BARBARA SILVERBERG
• 金额: $ 4.99万
• 依托单位: ABRATECH CORPORATION
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-02-01 至 1987-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3504114
• 关键词: auditory pathways; auditory stimulus; brain stem; computer assisted diagnosis; computers; diagnosis quality /standard; evoked potentials; hearing tests; stimulus /response

The goal of this research is to determine the feasibility of combining three-channel recording of the Auditory Brainstem Response (ABR) with a stimulus-pairs technique so as to measure the decrement in response that occurs in the Relative Refractory Period (RRP). This method will permit detection of any abnormalities which affect the RRP, since the parameters can be adjusted so that there is decrement in the response to the 2nd stimulus, in normals. The 3-Channel Lissajous Trajectory (3-CLT) of the ABR will be analyzed with respect to both linear and planar segments. The use of stimulus pairs provides information about the responses to both the 1st and the 2nd stimulus (in the RRP), and also permits analysis of the neuronal activity which is NOT activated in the RRP (by means of the "ghost" waveforms recovered by subtraction of the 1st and 2nd responses). This methodology is likely to be more sensitive to pathological changes in the auditory nervous system than is the ABR, which has had extensive use in audiology and neurology as a objective measure of brainstem normality or abnormality. Keywords: auditory brainstem response; evoked response; three- channel Lissajous trajectory; planar analysis; stimulus pairs; refractory period; three-dimensional analysis Potential commercial applications: The automated data acquisition and analysis system that will be designed using microcomputers is intend to be a basis for advanced evoked response recording systems of the future. At least six companies now produce ABR systems, primarily for clinical use, but the these systems cannot record or analyze either the 3-CLT or stimulus pairs, much less the two combined. This research will provide a hardware/software design which can be incorporated into a commercial product, as well as the scientific justification for its use. The design will either be sold or licensed to companies with production and sales capabilities.

本研究的目的是确定 结合听觉脑干的三通道记录 用刺激对技术检测ABR反应， 在相对不应期中发生的反应递减 期间（RRP）。 该方法将允许检测任何 影响RRP的异常，因为参数可以是 调整后，使第二个响应递减 刺激，在正常情况下。 3通道Lissajous轨迹（3-CLT） ABR的线性和平面分析 片段 刺激对的使用提供了关于 对第一和第二刺激的反应（在RRP中）， 并且还允许分析神经元活动， 在RRP中激活（通过“重影”波形 通过减去第一和第二响应恢复）。 这 方法学可能对病理变化更敏感 听觉神经系统中的ABR， 广泛用于听力学和神经学作为客观测量 脑干正常或异常 保留字： 听性脑干反应;诱发反应;三- 通道李萨如轨迹;平面分析;激励 配对;不应期;三维分析 潜在的商业应用： 自动化数据采集和分析系统， 使用微型计算机设计，旨在成为 先进的诱发反应记录系统 在 目前至少有六家公司生产ABR系统，主要用于 临床使用，但这些系统不能记录或分析 3-CLT或刺激对，更不用说两者结合了。 这 研究将提供硬件/软件设计， 结合到商业产品中，以及科学 使用的理由。 该设计将被出售或许可 有生产和销售能力的公司。