CONSTRUCTION AND CLINICAL TRIALS OF 31P NMR SPECTROMETER

31P核磁共振波谱仪的构建和临床试验

• 批准号: 3507788
• 负责人: ROGER WHEATLEY
• 金额: $ 11.79万
• 依托单位: OTSUKA ELECTRONICS, USA
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-04-01 至 1988-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3507788
• 关键词: brain metabolism; cardiovascular disorder diagnosis; cardiovascular imaging /visualization; cerebral hemorrhage; cerebrovascular disorder diagnosis; cerebrovascular imaging /visualization; clinical biomedical equipment; creatine phosphate; human subject; infant human (0-1 year); magnetic field; magnetism; metabolism; neoplasm /cancer; neoplasm /cancer diagnosis; noninvasive diagnosis; nuclear magnetic resonance spectroscopy; peripheral blood vessel; peripheral blood vessel disorder; phosphorus metabolism

Design and construction of a 3.0 Tesla high resolution superconducting magnet system with short horizontal 30cm bore to incorporate with Phospho-Energetics, Inc. phosphorous nuclear magnetic resonance spectrometer. Preliminary work has been performed at the University of Pennsylvania, Department of Biochemistry using 1.5 and 1.9 Tesla superconducting magnets for variety of in vivo studies of various diseases in animal model and humans. Relevant to this proposal are studies in animal model tumors and therapy thereof to follow their time courses non invasively. In addition, neuroblastoma tumors of the liver have been studied in infants and children as well as tumors on limbs of adults. Unlike 1H NMR imaging which yields anatomical data with limited specificity, 31P NMR yields direct measurement of metabolism that precedes anatomical changes. Unfortunately, 31P is present in very low concentrations, 10-20mM compared to protons at 100M, and is therefore much more difficult to detect. P-E has pioneered in the application of 31P NMR instrumentation to in vivo measurements of various metabolic disorders. More recently high resolution proton NMR where the bulk water signal is suppressed yielding underlying high resolution spectra of the same phosphorous metabolites plus lactate has indicated that observation of 31P and high resolution 1H would yield more useful information on the metabolism of tumors.

3.0特斯拉高分辨率超导磁共振成像系统的设计与建造 磁体系统，具有短的30 cm水平孔， Phospho-Energetics，Inc.磷核磁共振 光谱仪 初步工作已在宾夕法尼亚大学进行， 生物化学系使用1.5和1.9特斯拉超导磁体 用于动物模型中各种疾病的各种体内研究， 人类 与该提议相关的是动物模型肿瘤的研究， 其治疗以非侵入性地遵循其时间进程。 此外，本发明还提供了一种方法， 肝脏神经母细胞瘤肿瘤已经在婴儿和儿童中进行了研究 以及成年人四肢上的肿瘤。 与1H NMR成像不同，1H NMR成像产生的解剖数据有限， 特异性，31 P NMR产生直接测量代谢， 解剖学变化 不幸的是，31 P存在于非常低的 浓度，10- 20 mM，与100 M的质子相比，因此 更难被发现。 P-E率先将31 P NMR仪器应用于体内 各种代谢紊乱的测量。 最近高分辨率 质子NMR，其中本体水信号被抑制，产生潜在的 相同磷代谢物加乳酸盐的高分辨率光谱 已经表明，31 P和高分辨率1H的观测将产生 更多关于肿瘤代谢的有用信息。