CONSTRUCTION AND CLINICAL TRIALS OF 31P NMR SPECTROMETER

31P核磁共振波谱仪的构建和临床试验

• 批准号: 3507788
• 负责人: ROGER WHEATLEY
• 金额: $ 11.79万
• 依托单位: OTSUKA ELECTRONICS, USA
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-04-01 至 1988-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3507788
• 关键词: brain metabolism; cardiovascular disorder diagnosis; cardiovascular imaging /visualization; cerebral hemorrhage; cerebrovascular disorder diagnosis; cerebrovascular imaging /visualization; clinical biomedical equipment; creatine phosphate; human subject; infant human (0-1 year); magnetic field; magnetism; metabolism; neoplasm /cancer; neoplasm /cancer diagnosis; noninvasive diagnosis; nuclear magnetic resonance spectroscopy; peripheral blood vessel; peripheral blood vessel disorder; phosphorus metabolism

Design and construction of a 3.0 Tesla high resolution superconducting magnet system with short horizontal 30cm bore to incorporate with Phospho-Energetics, Inc. phosphorous nuclear magnetic resonance spectrometer. Preliminary work has been performed at the University of Pennsylvania, Department of Biochemistry using 1.5 and 1.9 Tesla superconducting magnets for variety of in vivo studies of various diseases in animal model and humans. Relevant to this proposal are studies in animal model tumors and therapy thereof to follow their time courses non invasively. In addition, neuroblastoma tumors of the liver have been studied in infants and children as well as tumors on limbs of adults. Unlike 1H NMR imaging which yields anatomical data with limited specificity, 31P NMR yields direct measurement of metabolism that precedes anatomical changes. Unfortunately, 31P is present in very low concentrations, 10-20mM compared to protons at 100M, and is therefore much more difficult to detect. P-E has pioneered in the application of 31P NMR instrumentation to in vivo measurements of various metabolic disorders. More recently high resolution proton NMR where the bulk water signal is suppressed yielding underlying high resolution spectra of the same phosphorous metabolites plus lactate has indicated that observation of 31P and high resolution 1H would yield more useful information on the metabolism of tumors.

3.0特斯拉高分辨率超导的设计和构建 水平30厘米孔的磁铁系统与 磷酸化Emgetics，Inc。磷核磁共振 光谱仪。 宾夕法尼亚大学已经进行了初步工作 使用1.5和1.9特斯拉超导磁铁的生物化学系 用于动物模型中各种疾病的各种体内研究 人类。 与该建议相关的是动物模型肿瘤的研究， 它的治疗是不可激动地遵循他们的时间课程。 此外， 肝脏的神经母细胞瘤肿瘤已在婴儿和儿童中进行了研究 以及成人四肢的肿瘤。 与1H NMR成像不同，该成像产生有限的解剖学数据 特异性，31p NMR得出的代谢直接测量 解剖变化。 不幸的是，31便士的存在很低 浓度，与100m处的质子相比，浓度为10-20mm，因此很大 更难检测到。 P-e已在31p NMR仪器的应用中率先进行体内 各种代谢疾病的测量。 最近高分辨率 质子NMR，其中大块水信号被抑制在下面的基础上产生 同一磷代谢物加乳酸的高分辨率光谱 已经表明，观察31p和高分辨率1H会产生 有关肿瘤代谢的更多有用信息。