CONTROL OF BRAIN ENERGY METABOLISM

大脑能量代谢的控制

• 批准号: 3503990
• 负责人: ROGER WHEATLEY
• 金额: $ 4.95万
• 依托单位: OTSUKA ELECTRONICS, USA
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-04-01 至 1985-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3503990
• 关键词: adenosine triphosphate; bioenergetics; brain imaging /visualization /scanning; brain metabolism; cerebral ischemia /hypoxia; cerebrovascular disorder diagnosis; creatine phosphate; hypoxia; hypoxia neonatorum; myocardial ischemia /hypoxia; noninvasive diagnosis; phosphates; respirators; respiratory disorder diagnosis; respiratory oxygen; respiratory therapy

This proposal describes a new method for stabilizing the energy state of the brain that is threatened by hypoxic distress due to failure of adequate O2 delivery. The energy state of the brain is evaluated by 31P NMR every 2 to 4 minutes and the ratio of phosphocreatine (PCr) to inorganic phosphate (Pi) or to adenosine triphosphate (ATP) is employed as a quantitative measure of this energy state. Model studies show that values for PCr/Pi above 1.0 afford stable function of brain (and heart) metabolism and values below 1.0 appear to be insufficient for long-term organ survival. Variation of the oxygen delivered to the tissues (FiO2) will control this ratio particularly in cases of insufficient lung function as in respiratory distressed neonates, but not limited thereto. The specific proposal for Phase I involves the testing of the manual control of FiO2 in response to the need for heart or brain PCr/Pi values that are above 1.0 first in animal models, secondarily (Phases iI and II) in respiratory distressed neonates and, as larer magnets become available, in adults who require oxygen therapy. Servo control of the brain or heart energy state is described and represents the seond phase (II) of development that affords an automatic control and presentation of even momentary loss or organ energy states in patients with diseases of O2 delivery to tissue.

该提案描述了一种新的方法，用于稳定的能量状态， 大脑由于缺乏足够的能量而受到缺氧的威胁， 氧气输送 大脑的能量状态通过31 P NMR每2 至4分钟以及磷酸肌酸（PCr）与无机磷酸盐的比率 (Pi)或腺苷三磷酸（ATP）用作定量测定。 这种能量状态的度量。 模型研究表明，PCr/Pi值 1.0以上提供稳定的大脑（和心脏）代谢功能和价值观 低于1.0似乎不足以使器官长期存活。 输送到组织的氧气（FiO 2）的变化将控制这一点 特别是在肺功能不足的情况下，如呼吸系统疾病， 窘迫的新生儿，但不限于此。 具体建议 第一阶段涉及对FiO 2手动控制的测试， 首先需要心脏或大脑PCr/Pi值高于1.0， 动物模型，其次（阶段iI和II）在呼吸窘迫 新生儿，以及随着磁铁的使用越来越广泛， 氧气疗法 伺服控制的大脑或心脏的能量状态是 描述并代表第二阶段（II）的发展， 即使是短暂的丧失或器官的自动控制和表现 能量状态的疾病患者的氧气输送到组织。