CONTROL OF BRAIN ENERGY METABOLISM

大脑能量代谢的控制

• 批准号: 3503990
• 负责人: ROGER WHEATLEY
• 金额: $ 4.95万
• 依托单位: OTSUKA ELECTRONICS, USA
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-04-01 至 1985-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3503990
• 关键词: adenosine triphosphate; bioenergetics; brain imaging /visualization /scanning; brain metabolism; cerebral ischemia /hypoxia; cerebrovascular disorder diagnosis; creatine phosphate; hypoxia; hypoxia neonatorum; myocardial ischemia /hypoxia; noninvasive diagnosis; phosphates; respirators; respiratory disorder diagnosis; respiratory oxygen; respiratory therapy

This proposal describes a new method for stabilizing the energy state of the brain that is threatened by hypoxic distress due to failure of adequate O2 delivery. The energy state of the brain is evaluated by 31P NMR every 2 to 4 minutes and the ratio of phosphocreatine (PCr) to inorganic phosphate (Pi) or to adenosine triphosphate (ATP) is employed as a quantitative measure of this energy state. Model studies show that values for PCr/Pi above 1.0 afford stable function of brain (and heart) metabolism and values below 1.0 appear to be insufficient for long-term organ survival. Variation of the oxygen delivered to the tissues (FiO2) will control this ratio particularly in cases of insufficient lung function as in respiratory distressed neonates, but not limited thereto. The specific proposal for Phase I involves the testing of the manual control of FiO2 in response to the need for heart or brain PCr/Pi values that are above 1.0 first in animal models, secondarily (Phases iI and II) in respiratory distressed neonates and, as larer magnets become available, in adults who require oxygen therapy. Servo control of the brain or heart energy state is described and represents the seond phase (II) of development that affords an automatic control and presentation of even momentary loss or organ energy states in patients with diseases of O2 delivery to tissue.

该建议描述了一种稳定能量状态的新方法 由于足够的失败而受到低氧陷入威胁的大脑 O2交付。 大脑的能量状态每21 nmr评估31p NMR 到4分钟，磷酸磷酸（PCR）与无机磷酸盐的比率 （PI）或三磷酸腺苷（ATP）用作定量 衡量这种能量状态。 模型研究表明PCR/PI的值 1.0以上具有大脑（和心脏）代谢和价值的稳定功能 1.0以下似乎不足以用于长期器官生存。 输送到组织的氧的变化（FiO2）将控制这一点 比率特别是在肺部功能不足的情况下如呼吸 苦恼的新生儿，但不受限制。 针对的具体建议 第一阶段涉及对FIO2的手动控制的测试 首先需要高于1.0的心脏或脑PCR/PI值的需求 动物模型，其次（第二阶段和II阶段） 新生儿，随着拉勒磁铁的可用 氧疗法。 伺服控制大脑或心脏能量状态是 描述并代表提供的SEOND阶段（II） 自动控制和偶然损失或器官 O2递送到组织的疾病患者的能量态。