EXERCISE USING 31P NMR AND AN ISOKINETIC ERGOMETER

使用 31P NMR 和等速测力计进行锻炼

• 批准号: 3500808
• 负责人: ROGER WHEATLEY
• 金额: $ 5万
• 依托单位: OTSUKA ELECTRONICS, USA
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-04-01 至 1986-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3500808
• 关键词: aging; bioenergetics; cardiovascular stress test; clinical biomedical equipment; creatine phosphate; exercise; human old age (65+); human subject; metabolism disorder diagnosis; muscle metabolism; nuclear magnetic resonance spectroscopy; nutrition; nutrition related tag; oxidative phosphorylation; phosphates; phosphoric ester; phosphorus metabolism; young adult human (21-34)

Based on research performed at the University of Pennsylvania on a Phospho-Energetics, Inc. (P-E) NMR spectrometer for the "Validation of 31p in Diseased and Normal Human Tissues", P-E has developed a combination NMR/work output measuring instrument. Studies have been performed with subjects suffering from peripheral vascular disease, genetic defects, cardiomyopathy as well as normal volunteers and athletes leading to a data base from which the ratios of various phosphates, e.g., phosphocreatine/inorganic phosphate (PCr/Pi), phospho diesters/Pi, and sugar phosphates/Pi etc. may be used to determine the state of tissue. It is proposed to extend this work into a study of "apparent" normal volunteers between the ages of 65 and 75 to try and correlate the existing data with ongoing measurements relative to an exercise protocol and nutritional protocol. In order to do this, it will be necessary to develop a new non magnetic linkage suitable for in magnet leg exercise. It is expected that the combined 31P NMR, non magnetic linkage and ergometer could become commercially important as a screening test to 1) identify incipient PVD or diabetes and 2) to evaluate the effect of exercise and the relationship between exercise and nutrition in the aging population.

基于宾夕法尼亚大学进行的一项研究 Phospho-Energetics, Inc. (P-E) NMR 波谱仪用于“31p 的验证” 在患病和正常人体组织中”，P-E 开发了一种组合 NMR/功输出测量仪。 研究已进行 患有周围血管疾病、遗传缺陷的受试者， 心肌病以及正常志愿者和运动员得出的数据 各种磷酸盐的比例，例如， 磷酸肌酸/无机磷酸盐 (PCr/Pi)、磷酸二酯/Pi 和 磷酸糖/Pi等可用于确定组织的状态。 建议将这项工作扩展到“表观”正常的研究 年龄在 65 岁至 75 岁之间的志愿者尝试将现有的 与锻炼方案相关的持续测量数据以及 营养协议。 为了做到这一点，有必要开发 一种新型非磁性连杆，适用于磁腿锻炼。 这是 预计 31P NMR、非磁联动和测力计相结合 作为一种筛选测试，可能会变得具有商业重要性：1） 初期 PVD ​​或糖尿病，2) 评估运动的效果和 老龄化人口中运动与营养的关系。