A NEUROMUSCULAR BLOCKADE MONITOR USING MOTION SENSOR

使用运动传感器的神经肌肉封锁监视器

• 批准号: 3509290
• 负责人: JOSEPH A ORR
• 金额: $ 24.94万
• 依托单位: AXON MEDICAL, INC.
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-05-15 至 1994-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3509290
• 关键词: automated data processing; biomedical automation; biomedical equipment development; biosensor device; clinical biomedical equipment; clinical trials; computer human interaction; computer program /software; computer simulation; drug delivery systems; electrostimulus; evaluation /testing; human subject; intensive care; muscle relaxants; muscle relaxation; neuromuscular blocking agents; neuromuscular stimulator; paralysis; patient monitoring device

There is a need to better monitor and control neuromuscular blockade, to measure whether a patient is adequately paralyzed during surgery and to facilitate mechanical ventilation in the Intensive Care Unit (ICU). In Phase I, we developed a neuromuscular monitor for the operating room. It monitor delivers an electrical stimulus and measures the patient's movement with a piezo film sensor. The monitor and disposable sensor were tested in 12 patients. It is found to be as accurate as other monitoring techniques. In Phase II, we will develop a neuromuscular blockade monitor for the ICU. Clinical studies will demonstrate that the ankle and foot are appropriate monitoring sites and that submaximal electrical stimulation provides adequate signal strength, but is less painful to the patient. In Phase II we will also develop a closed-loop controller for a drug infusion pump. The controller will automatically maintain the desired level of paralysis. This work will conclude with the development and testing of a single board computer version of the monitor and controller, to be sold on an OEM basis to syringe pump manufacturers.

有必要对神经肌肉阻滞进行更好的监测和控制

项目成果

Fuzzy logic for model adaptation of a pharmacokinetic-based closed loop delivery system for pancuronium.

基于药代动力学的泮库溴铵闭环输送系统模型适应的模糊逻辑。

• DOI: 10.1016/s0933-3657(97)00022-5
• 发表时间: 1997
• 期刊: Artificial intelligence in medicine.
• 作者: Kern,SE;Johnson,JO;Westenskow,DR
• 通讯作者: Westenskow,DR