TRACHEAL PRESSURE CONTROLLER FOR VENTILATORS

呼吸机气管压力控制器

• 批准号: 6142601
• 负责人: JOSEPH A ORR
• 金额: $ 10万
• 依托单位: AXON MEDICAL, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2001-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6142601
• 关键词: biomedical equipment development; patient monitoring device; respirators; respiratory airflow measurement; respiratory airway pressure; respiratory airway volume; trachea

Patients in intensive care often need to be mechanically ventilated for long periods of time. Mechanical ventilation is delivered through a cuffed tube placed in the trachea. As gas flows to and from the patient, the pressure drop across this tube causes extra work for the patient and causes distortion in lung pressure measurements. We have developed a system to measure the pressure in the lungs using a standard endotracheal tube. We propose to apply this technology to enhance mechanical ventilators and Improve the information used by physicians. We will build a system to measure the tracheal pressure from the endotracheal tube cuff. A device will be built to modify the pressure observed by a mechanical ventilator. We will test this system using two types of ventilators and a mechanical lung simulator. Testing will be done to determine if the modified ventilator correctly compensates for the pressure drop across the endotracheal tube, using various sizes of tubes. The system will also be tested simulating various clinical conditions resulting in obstructed endotracheal tubes. Following phase II, we will manufacture OEM circuit that can be integrated into ICU ventilators. PROPOSED COMMERCIAL APPLICATIONS: The proposed tracheal pressure controller could potentially become part of all ICU ventilators. The enhanced ventilator performance provided by the controller would add approximately $500 in value to the ventilator. There are over 88,000 Intensive Care Units in the US, each equipped with a ventilator. The total US market is thus $44 million. The total world market is about $132 million.

重症监护患者通常需要长时间机械通气。机械通气通过放置在气管中的带套囊的管输送。当气体流入和流出患者时，穿过该管的压降会给患者造成额外的工作，并导致肺压测量结果失真。我们已经开发了一个系统，使用标准气管内导管测量肺部压力。我们建议应用这项技术来增强机械搅拌器和改善医生使用的信息。我们将建立一个系统来测量气管内导管套囊的气管压力。将构建一种器械，以修改机械呼吸机观察到的压力。我们将使用两种类型的呼吸机和机械肺模拟器来测试该系统。将进行测试，以确定改良的呼吸机是否使用各种尺寸的气管插管正确补偿气管插管的压降。还将对该系统进行测试，模拟导致气管插管阻塞的各种临床条件。在第二阶段之后，我们将生产可集成到ICU呼吸机中的OEM电路。拟议的商业应用：拟议的气管压力控制器可能成为所有ICU呼吸机的一部分。由控制器提供的增强的呼吸机性能将为呼吸机增加大约500美元的价值。美国有超过88，000个重症监护室，每个都配备了呼吸机。因此，美国市场总额为4400万美元。全球市场总额约为1.32亿美元。