NEUROMUSCULAR BLOCKADE MONITOR USING MOTION SENSOR

使用运动传感器的神经肌肉阻断监视器

• 批准号: 3509289
• 负责人: JOSEPH A ORR
• 金额: $ 24.96万
• 依托单位: AXON MEDICAL, INC.
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-05-15 至 1994-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3509289
• 关键词: automated data processing; biomedical automation; biomedical equipment development; biosensor device; clinical biomedical equipment; clinical trials; computer human interaction; computer program /software; computer simulation; drug delivery systems; electrostimulus; evaluation /testing; human subject; intensive care; muscle relaxants; muscle relaxation; neuromuscular blocking agents; neuromuscular stimulator; paralysis; patient monitoring device

There is a need to better monitor and control neuromuscular blockade, to measure whether a patient is adequately paralyzed during surgery and to facilitate mechanical ventilation in the Intensive Care Unit (ICU). In Phase I, we developed a neuromuscular monitor for the operating room. It monitor delivers an electrical stimulus and measures the patient's movement with a piezo film sensor. The monitor and disposable sensor were tested in 12 patients. It is found to be as accurate as other monitoring techniques. In Phase II, we will develop a neuromuscular blockade monitor for the ICU. Clinical studies will demonstrate that the ankle and foot are appropriate monitoring sites and that submaximal electrical stimulation provides adequate signal strength, but is less painful to the patient. In Phase II we will also develop a closed-loop controller for a drug infusion pump. The controller will automatically maintain the desired level of paralysis. This work will conclude with the development and testing of a single board computer version of the monitor and controller, to be sold on an OEM basis to syringe pump manufacturers.

需要更好地监测和控制神经肌肉阻滞， 测量患者在手术期间是否充分瘫痪， 促进重症监护室（ICU）的机械通气。 在 第一阶段，我们为手术室开发了一种神经肌肉监测器。 它 监视器提供电刺激并测量患者的运动 压电薄膜传感器。 监测仪和一次性传感器在 12个病人 它与其他监测技术一样准确。 在第二阶段，我们将为ICU开发一种神经肌肉阻滞监测仪。 临床研究将证明踝关节和足部是适当的 监测部位和次最大电刺激提供的 足够的信号强度，但对患者的痛苦较小。 在第二阶段 我们还将开发用于药物输注泵的闭环控制器。 控制器会自动保持所需的瘫痪水平。 这项工作将结束与发展和测试的一个单一的董事会 计算机版本的监视器和控制器，以OEM方式销售 注射泵制造商。