FETAL HYPOXIA AND CIRCULATORY STATE MONITOR

该项目解决了真实的时间量化的关键需求， 胎儿缺氧是所有分娩过程中的一种令人担忧的情况， 脑损伤或死亡 目前，没有这样的直接监测缺氧 存在，但每年有一半的出生率受到一些间接的监测， 缺氧指标。 美国妇产科医师学会 妇科医生建议测量新生儿的动脉酸度 与持续抑郁的阿普加评分，以确定是否缺氧是一个 近因 在第一阶段，创科实业开发了一种覆盖 极谱氧传感器，还包括热敏电阻测量 局部血液灌注率以满足该临床需求。 这个头皮- 接触式传感器使用从Thermal Technologies的 增强型热扩散探头测量氧分压（1 mmHg）， 灌注（10%）和温度（0.0035 ℃）。 双层膜 也消除了极谱氧传感器的压力敏感性 作为操作员特定的校准可变性。 这种膜由一种 与盐水结合的组织接触硅酮透气膜， 饱和的水凝胶，以提供阴极和阴极之间的电连续性。 阳极 在第二阶段，传感器性能将进行优化， 稳定性和时间响应。 探头电流与电压比 极谱信号的放大将使用混合放大器来制造。 电子封装，以减少整体探头尺寸。 一种可伸缩的订书钉 将设计和测试连接机制。 第二阶段， 工作将致力于评价综合系统， 并验证其临床相关性。 这将通过 正在进行的实验中对妊娠母羊胎儿的测量 我们的临床合作者。

This project addresses the critical need for real time quantification of fetal hypoxia, a condition of concern during all births that can lead to brain damage or death. Currently, no such direct monitor of hypoxia exists, yet each year half of births are monitored with some indirect indicator of hypoxia. The American College of Obstetricians and Gynecologists has recommended that arterial acidity be measured in newborns with persistently depressed Apgar scores to determine if hypoxia is a proximate cause. During Phase I, TTI has developed a membrane covered polarographic oxygen sensor which also incorporates a thermistor to measure the local blood perfusion rate to address this clinical need. This scalp- contacting sensor uses protocols adapted from Thermal Technologies' Enhanced Thermal Diffusion Probe to measure oxygen tension (1 mmHg), perfusion (10%) and temperature (0.0035 degrees C). The Bilayer Membrane eliminates pressure sensitivity of the polarographic oxygen sensor as well as operator-specific calibration variability. This membrane consists of a tissue contacting silicone gas permeable membrane bonded to a saline- saturated hydrogel to provide electrical continuity between the cathode and anode. During Phase II, the sensor performance will be optimized for stability and temporal response. The on probe current to voltage amplification of the polarographic signals will be fabricated using hybrid electronic packaging to reduce overall probe size. A retractable-staple attachment mechanism will be designed and tested. Following this, Phase II work will be devoted to both the evaluation of the integrated system as well as verification of its clinical relevance. This will be done through measurements on the fetuses of pregnant ewes in ongoing experimentation with our clinical collaborators.