BINUCLEAR METAL-POLYPYRIDYL MOLYBDENUM OXO-THIOLATES AS MODEL FOR OXOTRANSFERASES

钼作为一种微量元素在人体内的作用是重要的 其一，它存在于“氧化转移酶”的活性部位。 亚硫酸盐氧化酶、黄嘌呤脱氢酶、乙醛 作为钼辅助因子的转移酶，这是 这些酶起作用。患有低血糖症的儿童 起作用的亚硫酸盐氧化酶和黄嘌呤脱氢酶 被发现表现出智力低下，神经异常， 晶状体移位，身体发育迟缓。 在本项目中，一系列化合物的合成和表征 MoS_2-非(Mu-S)_2Ru(II)Lx(Lx=2，2‘-联吡啶)类似物 (Bipy)或2，6-双(2‘-吡啶)吡啶(Terpy)H2O) 已执行。在这一系列化合物中，钼原子将 具有与为活动对象建议的坐标球体相似的坐标球体 黄嘌呤脱氢酶和亚硫酸盐氧化酶的位置将是 键合在单电子氧化还原活性Ru多吡啶络合物上 通过桥接硫化物基团。表征的方法将会 包括对电子吸收光谱的研究， 这些络合物的电化学性质和化学反应活性。这个 将调查氧化和还原产物的性质 通过在光吸收和EPR中的原位电解 光谱分析细胞。长期目标是调查 (一)该等系统的反应范围；及。(二) 共价键合过渡金属络合物As的活性 模型系统中的简单氧化还原储集层。

The role of molybdenum as a trace element in humans is an important one; it is present in the active site in the "oxotransferase" enzymes sulfite oxidase, xanthine dehydrogenase, aldehyde transferase as the molybdenum co-factor which is necessary for these enzymes to operate. Children who have low levels of functioning sulfite oxidase and xanthine dehydrogenase have been found to exhibit mental retardation, neurological abnormalities, displaced ocular lenses and retarded physical development. In this project, the synthesis and characterization of a series of analogous compounds, MoS2-nOn(mu-S)2Ru(ii)Lx(Lx=2, 2'-bipyridine (bipy) or 2,6-bis(2'-pyridyl)pyridine (terpy) + H2O) will be performed. In this series of compounds, the molybdenum atom will have coordination spheres similar to those proposed for the active sites of xanthine dehydrogenase and sulfite oxidase and will be bonded to one electron redox active ruthenium polypyridyl complexes by bridging sulfide groups. Methods of characterization will include investigations of the electronic absorption spectrum, electrochemistry and chemical reactivity of these complexes. The nature of the oxidation and reduction products will be investigated through in situ electrolysis in optical absorption and EPR spectroscopic cells. The long term objectives are to investigate (a) the scope of the reactivity of such systems and (b) the viability of covalently attached transition metal complexes as simple redox reservoirs in model systems.