THEOPHYLLINE/SKELETAL MUSCLE CONTRACTION AND ENERGY BALANCE
茶碱/骨骼肌收缩和能量平衡
基本信息
- 批准号:3842160
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Methylxanthines as caffeine and theophylline, are frequently ingested by
humans, used as therapeutic agents and used as experimental tools. The
contraction of mammalian skeletal muscle was thought to be relatively
insensitive to low doses of methylxanthines, particularly caffeine and
theophylline, but recently alterations in muscle contraction properties
have been observed with caffeine and theophylline doses equivalent to those
found in humans ingesting coffee and on therapeutic regimens. Thus an aim
of this work is, with the assistance of students, to investigate the action
of both high and low theophylline levels on muscle contraction and energy
balance in metabolicly-stable mammalian muscle models. For this purpose
isolated soleus and EDL muscles of the rat will be used. Theophylline-
evoked twitch potentiation and contracture dose response curves will be
ascertained for both isolated preparations. In addition, theophylline's
effect on high energy phosphate levels in these muscles will be compared to
effects obtained in frog skeletal muscle. The results with theophylline
will then be compared with results previously obtained with caffeine to
determine if any differences exist in the action of these two
methylxanthines on muscle contraction. A clearer picture of direct muscle
actions of theophylline should emerge, including if theophylline, like
caffeine, can exert a direct effect on limb muscle contraction at
therapeutic levels. Also, by using calcium agonists/antagonists to modify
theophylline's action in skeletal muscle should emerge. Students
assistants will be able to participate in all aspects. They will gain
experience in both standard physiological as well as biochemical techniques
and via other supportive activities be encouraged to pursue biomedical
research careers.
甲基黄嘌呤,如咖啡因和茶碱,经常被
人类,用作治疗剂和实验工具。这个
哺乳动物骨骼肌的收缩被认为是相对
对低剂量甲基黄嘌呤不敏感,特别是咖啡因和
茶碱,但最近肌肉收缩特性的变化
观察到咖啡因和茶碱的剂量相当于
在人类摄入咖啡和治疗方案中发现。因此,这是一个目标
这项工作的目的是,在学生的协助下,调查行动
茶碱水平高低对肌肉收缩和能量的影响
代谢稳定的哺乳动物肌肉模型中的平衡。为此目的,
将使用大鼠的比目鱼肌和EDL肌。茶碱-
诱发的抽动增强和痉挛的剂量反应曲线
两种分离制剂均已确定。此外,茶碱的
对这些肌肉中高能量磷酸盐水平的影响将与
在青蛙骨骼肌中获得的效果。使用茶碱的结果
然后与之前用咖啡因获得的结果进行比较,以
确定这两者的操作是否存在任何差异
甲基黄嘌呤对肌肉收缩的影响。一张更清晰的直肌图像
茶碱的作用应该出现,包括如果茶碱,如
咖啡因,可对肢体肌肉收缩产生直接影响
治疗水平。此外,通过使用钙激动剂/拮抗剂来修饰
茶碱在骨骼肌中的作用应该会显现。学生
助理将能够参与所有方面的工作。他们将从中获益
具备标准生理和生化技术方面的经验
并通过其他支持活动鼓励从事生物医学
从事研究工作。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ELIZABETH T HAYS其他文献
ELIZABETH T HAYS的其他文献
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{{ truncateString('ELIZABETH T HAYS', 18)}}的其他基金
THEOPHYLLINE/SKELETAL MUSCLE CONTRACTION AND ENERGY BALANCE
茶碱/骨骼肌收缩和能量平衡
- 批准号:
6240485 - 财政年份:1997
- 资助金额:
-- - 项目类别:
THEOPHYLLINE/SKELETAL MUSCLE CONTRACTION AND ENERGY BALANCE
茶碱/骨骼肌收缩和能量平衡
- 批准号:
6271767 - 财政年份:1997
- 资助金额:
-- - 项目类别:
THEOPHYLLINE/SKELETAL MUSCLE CONTRACTION AND ENERGY BALANCE
茶碱/骨骼肌收缩和能量平衡
- 批准号:
5212165 - 财政年份:
- 资助金额:
-- - 项目类别:
THEOPHYLLINE/SKELETAL MUSCLE CONTRACTION AND ENERGY BALANCE
茶碱/骨骼肌收缩和能量平衡
- 批准号:
3756457 - 财政年份:
- 资助金额:
-- - 项目类别:
THEOPHYLLINE/SKELETAL MUSCLE CONTRACTION AND ENERGY BALANCE
茶碱/骨骼肌收缩和能量平衡
- 批准号:
3778393 - 财政年份:
- 资助金额:
-- - 项目类别:
THEOPHYLLINE/SKELETAL MUSCLE CONTRACTION AND ENERGY BALANCE
茶碱/骨骼肌收缩和能量平衡
- 批准号:
3857007 - 财政年份:
- 资助金额:
-- - 项目类别:
THEOPHYLLINE/SKELETAL MUSCLE CONTRACTION AND ENERGY BALANCE
茶碱/骨骼肌收缩和能量平衡
- 批准号:
3734877 - 财政年份:
- 资助金额:
-- - 项目类别:
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