Multi-User Equipment to Refresh Underpinning Analytical Capabilities at the University of Warwick

多用户设备刷新华威大学的基础分析能力

• 批准号: EP/P030572/1
• 负责人: Pamela Thomas
• 金额: $ 254.61万
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FP030572%2F1
• 关键词: Multi; User; Equipment; Refresh; Underpinning

Our ability to rapidly and routinely obtain information about the composition, structure, morphology and function of molecules, materials and devices produced by man or by nature is central to many advances and breakthroughs in the Engineering and Physical Sciences (EPS). Therefore, the main aim of this proposal is to replace and upgrade obsolete or near end-of-life underpinning, multi-user equipment within our mass spectrometry, microscopy and device characterisation Facilities/Research Technology Platforms (RTP), to ensure that researchers at Warwick (UW) have access to a state-of-the-art Analytical Science (AS) infrastructure. UW's long-term excellence in AS is firmly rooted in strategic investment (e.g. people, equipment, infrastructure, training, etc.) in this underpinning field. The AS equipment requested includes:1) Four instruments for our Mass Spectrometry (MS) Facility, including an Inductively Coupled Plasma Mass Spectrometer, Gas Chromatography Quadrupole Mass Spectrometer, MicroTOF Focus and 3D ion trap Mass Spectrometer, which will increase both our analytical capacity and level of sensitivity.2) Three core workhorse microscopy devices from within our RTP programme: including a Transmission Electron Microscope, Atomic Force Microscope, and confocal Raman; allowing us to increase both our core analysis capacity through higher speed imaging, and improved image resolution.3) A Parameter Analyser and Probing System to be hosted within the University's Power Electronic Characterisation suite (PEATER), to enable both greater processing capacity and the analysis of devices at higher voltages and currents.The proposed AS equipment will be used to facilitate and strengthen a wide range of EPS research at UW, that falls within EPSRC's strategic remit and is comprehensively aligned to the research strategy of the University; contributing to core themes within the University's 'Global Research Priorities' (GRPs) including Energy, Innovative Manufacturing, Science and Technology for Health, and Materials. The new AS equipment will underpin the research of >50 academic groups from across four key departments (Chemistry, Physics, Engineering and WMG) within the Faculty of Science, working in diverse fields, including: catalysis, chemical and synthetic biology, energy materials, manufacturing, medical imaging, nanoparticles, nanocomposites, polymer materials, power electronics, semiconductors, structural engineering, synthetic organic and coordination chemistry. This investment in state-of-the art equipment will also be fundamental to facilitating the training of many M-Level undergraduates, MSc and PhD students, and early career researchers in cutting-edge AS techniques. Each Facility/RTP has well established programmes of user training and support, and these are open to all UW student and staff users. This training will also be offered to external academics and industry partners. UW is committed to ensuring that the equipment requested is effectively managed and maintained, and that usage is maximised across the University and by external research partners. The equipment will either be managed through shared Facilities (MS and PEATER), or through the appropriate RTP (Electron Microscopy and proposed Optical Spectroscopy) to which UW has provided significant investment. Overall, UW's contribution to its RTPs totals more than £8.84M (staff, equipment, maintenance and consumables) since their inception in 2014. Access will be advertised internally through the GRPs, and externally through Warwick Scientific Services (WSS) - a centre of excellence based at UW, delivering cutting-edge world class scientific services, technical measurement solutions, innovative translational research, and knowledge and training services to businesses that could benefit from expertise and instrumentation. It will also be listed on equipment.data, a national equipment sharing portal.

我们能够快速和常规地获得有关由人类或自然产生的分子，材料和设备的组成，结构，形态和功能的信息，这是工程和物理科学（EPS）的许多进步和突破的核心。因此，本提案的主要目的是更换和升级我们的质谱仪，显微镜和设备表征设施/研究技术平台（RTP）内的过时或接近寿命结束的多用户设备，以确保沃里克（UW）的研究人员能够使用最先进的分析科学（AS）基础设施。UW在AS方面的长期卓越表现深深植根于战略投资（例如人员，设备，基础设施，培训等）。在这个基础领域。要求的AS设备包括：1）我们的质谱（MS）设施的四台仪器，包括电感耦合等离子体质谱仪，气相色谱四极杆质谱仪，MicroTOF Focus和3D离子阱质谱仪，这将提高我们的分析能力和灵敏度水平。2）我们RTP计划中的三台核心主力显微镜设备：包括透射电子显微镜，原子力显微镜和共焦拉曼;使我们能够通过更高速的成像来提高我们的岩心分析能力，3）参数分析仪和探测系统将在大学的电力电子特性套件（PEATER）中托管，以便在更高的电压和电流下实现更大的处理能力和器件分析。拟议的AS设备将用于促进和加强UW的广泛EPS研究，该研究福尔斯EPSRC的战略职权范围，并与大学的研究战略全面一致;为大学的“全球研究优先事项”（GRP）中的核心主题做出贡献，包括能源，创新制造，健康科学技术和材料。新的AS设备将支持来自四个关键部门的超过50个学术团体的研究（化学，物理，工程和WMG）在科学学院，在不同的领域工作，包括：催化、化学和合成生物学、能源材料、制造、医学成像、纳米颗粒、纳米复合材料、聚合物材料、电力电子、半导体、结构工程、合成有机化学和配位化学。这种对最先进设备的投资也将是促进许多M级本科生，硕士和博士生以及尖端AS技术的早期职业研究人员培训的基础。每个设施/RTP都有完善的用户培训和支持计划，这些计划对所有UW学生和员工用户开放。这一培训也将提供给外部学者和行业合作伙伴。UW致力于确保所要求的设备得到有效的管理和维护，并在整个大学和外部研究合作伙伴中最大限度地利用。这些设备将通过共享设施（MS和PEATER）或通过适当的RTP（电子显微镜和拟议的光谱学）进行管理，UW已为其提供了大量投资。总体而言，自2014年成立以来，UW对其RTP的贡献总计超过884万英镑（人员，设备，维护和消耗品）。访问将通过GRP在内部进行广告，并通过沃里克科学服务（WSS）进行外部宣传-这是一个位于华盛顿大学的卓越中心，为可以从专业知识和仪器中受益的企业提供尖端的世界级科学服务，技术测量解决方案，创新的转化研究以及知识和培训服务。它还将在国家设备共享门户网站equipment.data上列出。

项目成果

Transfer hydrogenation catalysis in cells.

• DOI: 10.1039/d0cb00150c
• 发表时间: 2021-02-01
• 期刊: RSC chemical biology
• 影响因子: 4.1
• 作者: Banerjee S;Sadler PJ
• 通讯作者: Sadler PJ

Metallodrugs are unique: opportunities and challenges of discovery and development.

• DOI: 10.1039/d0sc04082g
• 发表时间: 2020-11-12
• 期刊: Chemical science
• 影响因子: 8.4
• 作者: Anthony EJ;Bolitho EM;Bridgewater HE;Carter OWL;Donnelly JM;Imberti C;Lant EC;Lermyte F;Needham RJ;Palau M;Sadler PJ;Shi H;Wang FX;Zhang WY;Zhang Z
• 通讯作者: Zhang Z

Experimental and theoretical evidence for unprecedented strong interactions of gold atoms with boron on boron/sulfur-doped carbon surfaces

• DOI: 10.1039/d3na00956d
• 发表时间: 2023-12
• 期刊: Nanoscale Advances
• 影响因子: 4.7
• 作者: Samya Banerjee;J. Wolny;Mohsen Danaie;Nicolas P. E. Barry;Yisong Han;Houari Amari;Richard Beanland;Volker Schünemann;Peter J Sadler

Metallation-induced heterogeneous dynamics of DNA revealed by single-molecule FRET.

• DOI: 10.1002/chem.202000458
• 发表时间: 2020-01
• 期刊: Chemistry
• 作者: Raul Berrocal-Martin;C. Sanchez‐Cano;Cookson K. C. Chiu;R. J. Needham;P. Sadler;S. Magennis

Correction to "Vibrational Motions Make Significant Contributions to Sequential Methyl C-H Activations in an Organometallic Complex".

更正“振动运动对有机金属络合物中的甲基 C-H 连续活化做出重大贡献”。

• DOI: 10.1021/acs.jpclett.3c00826
• 发表时间: 2023
• 期刊: The journal of physical chemistry letters
• 作者: Armstrong J