COMPUTATIONAL GRAPHICS FOR BIOCHEMISTRY

生物化学计算图形

• 批准号: 3521612
• 负责人: JOSEPH KRAUT
• 金额: $ 21.4万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-06-22 至 1993-09-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3521612
• 关键词: biochemistry; biomedical equipment purchase; chemical models; chemical structure function; computer graphics /printing; computer program /software; computer simulation; computer system hardware; drug interactions

Ten research groups studying the structure, dynamics and function of biomolecules and their interactions with drugs are applying for computer graphics equipment which they will share. Funding is requested to i) upgrade the super graphic/computation/file server of a distributed graphical/computational resource; ii) improve the performance of the Chemistry local area network by 10X; iii) purchase a film station; iv) purchase a film station; iv) purchase a color laser printer; and v) purchase additional modeling software. This shared resource is primarily used for i) fitting of protein structure to electron density maps from X-ray diffraction; ii) studies of the structure and function of peptide hormones and analogs. iii) development of synthetic processes for the production of biologically active molecules important to the understanding of cancer and other disease; iv) development of models relevant to the study of biophysical mechanism of protein translocation through membranes; v) studies of intramolecular conformational analysis and stereodynamics; vi) studies in the relationship of structure to function in protein keinases using molecular biology techniques; vii) studies in the transport and activation of oxygen in biological systems; and viii) studies in the three-dimensional structure of protein molecules and the relationship between their structure and biological activities. The upgraded system will directly aid research which is supported by 20 existing and 3 pending NIH awards.

十个研究小组研究的结构，动态和功能 生物分子及其与药物的相互作用正在申请计算机 他们将分享的图形设备。 要求资金给我） 升级分布式的超级图形/计算/文件服务器 图形/计算资源； ii）提高性能 化学局部网络由10倍； iii）购买电影台； iv） 购买电影台； iv）购买颜色激光打印机；和v） 购买其他建模软件。 该共享资源主要用于i）拟合蛋白质结构 从X射线衍射到电子密度图； ii）研究 肽激素和类似物的结构和功能。 iii）发展 生产生物活性分子的合成过程 对了解癌症和其他疾病的理解很重要； iv）发展 与蛋白质生物物理机制研究有关的模型 通过膜易位； v）分子内的研究 构象分析和立体动力学； vi）关系研究 使用分子生物学在蛋白质基因酶中发挥作用的结构 技术； vii）研究氧气中氧气的运输和激活 生物系统；和viii）研究的三维结构 蛋白质分子及其结构之间的关系 生物活动。 升级的系统将直接帮助研究20 现有和3个待定的NIH奖项。