PURCHASE OF AN EI/CI/FAB MASS SPECTROMETER

购买 EI/CI/FAB 质谱仪

• 批准号: 3519460
• 负责人: RICHARD E MOORE
• 金额: $ 30万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-02-01 至 1987-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3519460
• 关键词: chemical structure; drug design /synthesis /production; gas chromatography; gas chromatography mass spectrometry; ionization; mass spectrometry

The aim of this proposal is to acquire a medium resolution mass spectrometer equipped with electron-impact, chemical ionization, and fast-atom bombardment ion sources and interfaced to a gas chromatograph and a data acquisition and processing system to support the research of three current NIH grantees at the University of Hawaii. The instrument will be used primarily for four areas of research: (1) for structural analysis and identification of pharmacologically active natural products, in particular anticancer drugs isolated from marine organisms and cultured blue-green algae; (2) for structural studies of the binding site of the visual pigment and related vitamin A binding proteins; (3) for characterization of intermediates in the total synthesis of pharmacologically active natural products; and (4) for structural studies of the binding site of the phorbol ester receptor.

该提案的目的是获得中等分辨率的质量 配备有电子碰撞、化学电离和 快速原子轰击离子源，并连接到气相色谱仪， 数据采集和处理系统，以支持三个研究 夏威夷大学的现任NIH资助人。 仪器将 主要用于四个研究领域：（1）结构分析和 鉴定具有生物活性的天然产物，特别是 从海洋生物和培养的蓝绿色生物中分离的抗癌药物 藻类;（2）用于视觉色素结合部位的结构研究 和相关的维生素A结合蛋白;（3）用于表征 活性天然药物全合成中间体 产品;和（4）用于佛波醇结合位点的结构研究 酯受体