ACQUISITION OF GC/MS WITH CI/EI AND FAB SOURCES

埃默里社区目前可用的GC/MS设施没有 足够的数据处理设施，分辨率和质量范围来处理 目前资助的一系列生物医学项目。 的最新进展 质谱分析已经导致了新一代的商业仪器 这将使质谱学成为生物医学中一个更重要的工具， 研究-特别是高分辨率磁扇区系统， 快速回收。 这种设施，结合容易互换 来源，提供了研究非挥发性生物分子的机会， 重量大于1000 amu的药物等。 就像高场 超导核磁共振仪器已经成为生物医学的一个组成部分， 研究和广泛使用的非核磁共振专家，质量 所要求的这种类型的光谱仪将在不久的将来得到广泛的接受。 未来 埃默里大学的生物医学研究社区已经并将继续 超过一半的主要用户最近才来到埃默里大学。 MS设施不足是我们目前面临的最大限制 在我们的研究项目中。 所要求的仪器将为六个主要用户服务。 的 仅化学系就将增加两个，可能还有三个 教师将成为用户。 一系列不同的研究项目将在 增强 这些包括：（a）FAB/MS在研究 （B）抗癌药物与核酸结合的研究; 荧光化合物在细菌中的分布，（c） 多核芳族化合物在炼油领域，（d）制备 标记的表面活性剂，（e）抗生素的合成，（f）偶极 环加成化学，（g）合成含有天然丁烯二酸的丁烯二酸， 产物，（h）氧化还原酶机制，和（i）有机钴 与辅酶B12化学有关的化学。 如果获奖，VG、Finnigan/MAT和 Kratos将使用我们的样品进行评估，并与用户进行讨论。 这些工具在学术机构。

The current GC/MS facility available to the Emory community does not have adequate data handling facility, resolution, and mass range to deal with the series of biomedical projects currently funded. Recent advances in mass spectrometry have led to a new generation of commercial instruments which will make mass spectroscopy a much more important tool in biomedical research - in particular, high resolution magnetic sector systems which can be quickly recycled. This facility, combined with readily interchanged sources, offers the opportunity to investigate non-volatile biomolecules, drugs, etc. with wieghts greater than 1000 amu. Just as high field superconducting NMR instruments have been an integral part of biomedical research and are used extensively by non-NMR specialists, mass spectrometers of the type requested will gain wide acceptance in the near future. The biomedical research community at Emory has and will continue to expand and over half the major users have come to Emory only recently. The inadequate MS facilities are currently the greatest limitation we face in our research program. The requested instrument will serve a group of six major users. The department of chemistry alone will add two and possibly three additional faculty that will be users. A diverse set of research programs will be enhanced. These include: (a) the application of FAB/MS to the study of anti-cancer drug binding to nucleic acids; (b) the study of the distribution of fluorescent compounds in bacteria, (c) distribution of polynuclear aromatic compounds in oil refinery areas, (d) the preparation of labeled surfactants, (e) syntheses of antibiotics, (f) dipolar cycloaddition chemistry, (g) the synthesis of butenolide containing natural products, (h) oxidation-reduction enzyme mechanisms, and (i) organocobalt chemistry related to coenzyme B12 chemistry. If an award is made, competitive instruments from VG, Finnigan/MAT, and Kratos will be evaluated with our samples and by discussion with users of these instruments in academic institutions.