QUANTIMET 900 IMAGE ANALYSING SYSTEM

Quantimet 900 图像分析系统

• 批准号: 3519281
• 负责人: LUCY L BROWN
• 金额: $ 13.7万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-02-01 至 1986-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3519281
• 关键词: autoradiography; brain mapping; brain metabolism; densitometry; genetics; image enhancement; image processing; neuroanatomy

Image analysis is necessary for full data extraction from new autoradiographic techniques available to trace biological events and to analyze structure/function relationships in brain; it is also necessary for full data extraction in studies which evaluate morphological features of cells, in their normal and/or abnormal states; it is especially accurate and time efficient for standard analysis techniques, e.g. microdensitometry of gels with high background complications. A major advance of the image analysis system commercially available from Cambridge Instruments, the Quantimet 900, is that it is relatively simple to use, and it performs multiple functions such as microdensitometry and three dimensional reconstructions. This user group has special needs for microdensitometry of variable-sized brain areas with simultaneous area measurements, and three dimensional reconstructions; image averaging to reduce noise or to detect change; image enhancement; area and shape analysis; high resolution. The projects and questions being asked are diverse; from neuroanatomical-functional questions in normal and diseased brain, and in "simple" invertebrate systems, to cell motility questions and basic genetics. There are six major user groups; two of the groups involve several investigators. The image analysis system requested will not only help current projects of the major user group and other researchers at this institution, but it will also be a powerful addition for future studies which would be impossible without it.

图像分析是从新的图像中提取完整数据的必要条件。 放射自显影技术可用于追踪生物事件， 分析大脑的结构/功能关系;这也是必要的， 在评价形态学特征的研究中提取完整数据 细胞，在其正常和/或异常状态;这是特别准确的 对于标准分析技术，例如显微密度测定， 具有高背景复杂性的凝胶。 图像的一个重大进步 分析系统可从剑桥仪器公司商购获得 Quantimet 900的优点在于它使用起来相对简单， 多种功能，如显微密度测定和三维 重建。 该用户组对可变尺寸的显微密度测定有特殊需求。 脑区与同时面积测量，和三维 重建;图像平均以减少噪声或检测变化;图像 增强;面积和形状分析;高分辨率。 的项目和 被问到的问题是不同的;从神经解剖功能 问题在正常和患病的大脑，并在“简单的”无脊椎动物 系统，细胞运动问题和基础遗传学。 有六 主要用户群体;其中两个群体涉及若干调查员。 的 图像分析系统的要求将不仅有助于目前的项目， 主要用户组和其他研究人员在这个机构，但它将 也是对未来研究的有力补充， 没有它

项目成果

Migraine treatment 'tweak' could reduce office visits.

偏头痛治疗“调整”可以减少就诊次数。

• 发表时间: 2009
• 期刊: The Journal of family practice
• 作者: Wells,Jack;Stevermer,James
• 通讯作者: Stevermer,James

Potential diagnostic utility of intermittent administration of short-acting gonadotropin-releasing hormone agonist in gonadotropin deficiency.

间歇性施用短效促性腺激素释放激素激动剂在促性腺激素缺乏症中的潜在诊断效用。

• DOI: 10.1016/j.fertnstert.2010.04.019
• 发表时间: 2010
• 期刊: Fertility and sterility
• 影响因子: 6.7
• 作者: Zimmer,CarrieA;Ehrmann,DavidA;Rosenfield,RobertL
• 通讯作者: Rosenfield,RobertL

Lung adenocarcinoma subtypes based on expression of human airway basal cell genes.

• DOI: 10.1183/09031936.00144012
• 发表时间: 2013-11
• 期刊: The European respiratory journal
• 作者: Fukui T;Shaykhiev R;Agosto-Perez F;Mezey JG;Downey RJ;Travis WD;Crystal RG
• 通讯作者: Crystal RG

Initiating antidepressant therapy? Try these 2 drugs first.

开始抗抑郁治疗？

• 发表时间: 2009
• 期刊: The Journal of family practice
• 作者: Patrick,Gail;Combs,Gene;Gavagan,Thomas
• 通讯作者: Gavagan,Thomas

Regional cerebral glucose utilization reveals widespread abnormalities in the motor system of the rat mutant dystonic.

局部脑葡萄糖利用揭示了肌张力障碍突变体大鼠运动系统的广泛异常。

• DOI: 10.1523/jneurosci.09-11-04033.1989
• 发表时间: 1989
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Brown,LL;Lorden,JF
• 通讯作者: Lorden,JF