GAS CHROMATOGRAPH-MASS SPECTROMETER-DATA SYSTEM

气相色谱-质谱仪-数据系统

• 批准号: 3519241
• 负责人: GLENN DRYHURST
• 金额: $ 22.5万
• 依托单位: UNIVERSITY OF OKLAHOMA
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-02-01 至 1986-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3519241
• 关键词: chemical synthesis; drug design /synthesis /production; electrochemistry; gas chromatography mass spectrometry; heterocyclic compounds; mass spectrometry; oxidation reduction reaction

The Chemistry Department at the University of Oklahoma at present houses three programs which require substantial use of the analytical technique called GC/MS (coupled gas chromatography-mass spectrometry). These three programs cover research concerning the electrochemical and enzymatic oxidation of biologically important N-heterocyclic molecules, the synthesis of cancer-inducing agents, and the discovery and development of drugs for the treatment of cancer and cardiovascular disease. The importance of these programs cannot be overstated, and their success may be limited by the insufficient access to GC/MS capability which now exists. We propose to provide much improved capability through the acquisition and supported operation of a new GC/MS facility will not only provide a substantial increase in the accessibility of this technique to these programs, but also a substantial increase in the general capability of the instrumentation.

俄克拉荷马大学目前的化学系 需要大量使用分析技术的三个程序 称为GC/MS(气相色谱-质谱联用)。这三个人 课程包括与电化学和酶相关的研究 生物上重要的N-杂环分子的氧化，合成 致癌物质，以及治疗癌症的药物的发现和开发 癌症和心血管疾病的治疗。重要的是 这些计划怎么夸大都不为过，它们的成功可能会受到以下因素的限制 对现在存在的GC/MS能力的访问不足。我们建议 通过收购和支持提供大大改进的能力 新的GC/MS设施的运行不仅将提供大量的 提高了该技术对这些程序的可访问性，但也 仪器设备总体能力的大幅提高。