SHARED PS300 COMPUTER GRAPHICS SYSTEM

共享 PS300 计算机图形系统

• 批准号: 3519288
• 负责人: GERALD J STUBBS
• 金额: $ 12.49万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-12-01 至 1985-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3519288
• 关键词: chemical models; chemical structure; computer graphics /printing; drug design /synthesis /production; enzyme structure; nucleic acid structure

An Evans & Sutherland PS300 computer graphics system will be purchased and maintained for an initial three-year period. In addition, the package to upgrade the system to a PS340, with the capacity to model solid surfaces such as enzyme active sites and virus surfaces, will be purchased, as well as a conventional terminal to allow maximum efficiency in using the graphics terminal. The system will be used in the research programs listed above, for building newly determined protein and nucleic acid models, for building possible models of proteins based on known structures of similar proteins, for the design of drugs and the study of drug binding sites, and for the interpretation of X-ray diffraction and nuclear magnetic resonance data from a variety of molecules, ranging from oligopeptide antibodies to viruses. Most of the major users are already using instruments of this type through collaborative arrangements with other institutions, but only at a high cost in time and travel. The system will also be used by a large group of other users needing occasional use of a molecular modeling facility, in most cases for the study of interactions between proteins and small molecules.

将购买Evans & Sutherland PS300计算机图形系统， 最初维持三年。 此外，该软件包还 将系统升级到PS340，能够对固体表面进行建模 例如酶活性位点和病毒表面，也将被购买 作为传统的终端，以允许在使用 图形终端 该系统将用于上述研究项目，用于建筑 新确定的蛋白质和核酸模型，用于建立可能的 基于相似蛋白质的已知结构的蛋白质模型， 药物设计和药物结合位点的研究，以及 X射线衍射和核磁共振数据解释 从寡肽抗体到 病毒 大多数主要用户已经在使用这种仪器 通过与其他机构的合作安排， 在时间和旅行上付出了高昂的代价。 该系统还将被大量其他需要的用户使用。 偶尔使用分子建模工具，在大多数情况下， 研究蛋白质和小分子之间的相互作用。