GAS CHROMATOGRAPHY/MASS SPECTROMETRY SYSTEM

气相色谱/质谱系统

• 批准号: 3519181
• 负责人: Paul J Cannon
• 金额: $ 23.53万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-12-01 至 1985-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3519181
• 关键词: antiarrhythmic agent; arachidonate; carbohydrate structure; drug metabolism; eicosanoid metabolism; gas chromatography mass spectrometry; leukotrienes; mass spectrometry; steroids; toxicology

This application requests support for the purchase of a Hewlett Packard 5987A gas chromatography mass spectrometer system (GC/MS). This instrument will form the core of a new GC/MS facility which will be available to the faculty of the College of Physicians and Surgeons. No such facility currently exists on this campus. The GC/MS will initially be used to study a wide range of problems including: arachidonic acid metabolism to leukotrienes and prostaglandins, carbohydrate structure in human choriogonadotropins, identification of novel sulfate, esterified steroids, neonatal toxicology of halogenated aromatics, and the metabolism of cardiac anti-arrhythmic drugs. The research programs are advanced by groups of established investigators from 7 departments of the University and are supported by over 30 peer-reviewed NIH grants. The addition of a GC/MS will greatly extend the research capabilities of these and other investigators at this institution. Access to the GC/MS facility by investigators will be guaranteed by an Advisory Committee reporting to the Dean. The equipment will be maintained by trained professional and technical personnel and will be availabale 24 hours/day to a broad user group. Space for the shared GC/MS facility will be provided by the Department of Medicine; installation costs will be covered by Columbia University.

此应用程序请求支持购买惠普 气相色谱-质谱仪(GC/MS)。这台仪器 将形成新的GC/MS设施的核心，该设施将可用于 内科医生和外科医生学院。没有这样的设施 目前存在于此校园中。 GC/MS最初将用于研究广泛的问题 包括：花生四烯酸代谢成白三烯和前列腺素， 人绒毛膜促性腺激素的碳水化合物结构鉴定 新型硫酸盐、酯化类固醇、卤代化合物的新生儿毒理学 芳香族和心脏抗心律失常药物的新陈代谢。这个 研究项目由来自中国的一批成熟的研究人员推动 大学的7个系，并得到30多个同行评议的支持 美国国立卫生研究院拨款。增加GC/MS将极大地扩展研究范围 该机构的这些和其他调查人员的能力。 调查人员对GC/MS设施的使用将由 咨询委员会向院长报告。将对设备进行维护 由训练有素的专业和技术人员提供，24 为广泛的用户群体提供每天几个小时的服务。共用GC/MS设施的空间将 由医学部提供；安装费将为 由哥伦比亚大学负责。